BASIC DENTAL IMPLANTOLOGY
PRDM 149 | First Semester
OSSEOINTEGRATION
PRELIMS - next week
MODULE 3 Growth Factor Cell Origin Function
TOPIC OUTLINE Tumor necrosis Macrophages Increases bone
● Bone healing and remodelling resorption
● The implant osseointegration
● Soft tissue considerations Fibroblast Inflammatory Increases cell
growth factor cells, replication and
osteoblasts, collagen
INJURY: Bone Healing chondrocytes formation
GOAL: to osseointegrate the implant with the bone
Angiogenic
Platelet-derive Platelets, Increases
STAGES OF BONE HEALING: d GF monocytes, cellular
1. Hematoma Formation endothelial proliferation
2. Fibrocartilaginous cells and collagen
3. Bony callus formation formation
4. Bone remodelling
Insulin-like GF Osteoblasts, Stimulates
chondrocytes chondrocyte
HEMATOMA FORMATION (Days 1-5) formation
1. Blood vessels supplying the bone and
periosteum are ruptured Transforming Platelets, Increases
2. Hematoma to form (temporary frame for GF Beta osteoblasts, proteoglycan
chondrocytes synthesis,
subsequent healing)
decreases
3. Secretion of pro-inflammatory cytokines (TNF,
collagen
BMP'S, IL-1,6,11,23) synthesis
4. Cytokines act to stimulate essential cellular
biology at the site, attracting macrophages, Bone Mesenchymal Induces
monocytes, and lymphocytes morphogenetic stem cells, progenitor cells
proteins -2, -4, osteoblasts to become
5. Vascular endothelial growth factor (VEGF) to
-7 bone-forming
stimulate healing at the site
cells
● From the day you started the surgery BMP’S
act as your signal GROWTH FACTORS IN HEMATOMA FORMATION
● Hematoma - most impt stage of bone healing
w/o it bone will never heal Intracartilaginous formation
● If immunocompromised, 1st stage of healing is - IGF is very very important when you produce
compromised – WALANG HEMATOMA injury in the MAXILLARY AREA (angiogenic
● Secretion of pro-inflammatory cytokines (TNF, ata?)
BMP’s, Interleukins 1, 6, 11,23) for Chondrocytes
inflammatory processes and chemotaxis - Serves as homeostasis – dapat may balance
between the 2
Increase in cellular formation
- Healing will be much faster?
Proliferate into osteoblast
Dr george s. navarra | DENT5aa 1
, BASIC DENTAL IMPLANTOLOGY
PRDM 149 | First Semester
OSSEOINTEGRATION
FIBROCARTILAGINOUS CALLUS FORMATION
(Day 5 to 11)
1. Release of VEGF leads to angiogenesis
2. Fibrin-rich granulation tissue begins to develop
3. Mesenchymal stem cells = fibroblasts,
chondroblasts, osteoblasts
4. Chondrogenesis
5. Osteoprogenitor cells
VEGF - vascular
started after hematoma clot
Once blood vessel is established
FIBROCARTILAGINOUS STAGE NA
Some parts will be chondrogenesis in the maxillary
Osteoprotegerin - induce osteoblastic formation
inducing bone tissue
Chondrogenesis will aid in the formation of new bone
tissue
NORMAL CHONDROCYTES FORMATION
Once hematom, may secretion to become
differentiated cells (chondroprogenitor) to
chrodnoblast or osteoblast the chondrocytes or
osteocyetes
DIFFERENTATION AND MATURATION
Dr george s. navarra | DENT5aa 2
PRDM 149 | First Semester
OSSEOINTEGRATION
PRELIMS - next week
MODULE 3 Growth Factor Cell Origin Function
TOPIC OUTLINE Tumor necrosis Macrophages Increases bone
● Bone healing and remodelling resorption
● The implant osseointegration
● Soft tissue considerations Fibroblast Inflammatory Increases cell
growth factor cells, replication and
osteoblasts, collagen
INJURY: Bone Healing chondrocytes formation
GOAL: to osseointegrate the implant with the bone
Angiogenic
Platelet-derive Platelets, Increases
STAGES OF BONE HEALING: d GF monocytes, cellular
1. Hematoma Formation endothelial proliferation
2. Fibrocartilaginous cells and collagen
3. Bony callus formation formation
4. Bone remodelling
Insulin-like GF Osteoblasts, Stimulates
chondrocytes chondrocyte
HEMATOMA FORMATION (Days 1-5) formation
1. Blood vessels supplying the bone and
periosteum are ruptured Transforming Platelets, Increases
2. Hematoma to form (temporary frame for GF Beta osteoblasts, proteoglycan
chondrocytes synthesis,
subsequent healing)
decreases
3. Secretion of pro-inflammatory cytokines (TNF,
collagen
BMP'S, IL-1,6,11,23) synthesis
4. Cytokines act to stimulate essential cellular
biology at the site, attracting macrophages, Bone Mesenchymal Induces
monocytes, and lymphocytes morphogenetic stem cells, progenitor cells
proteins -2, -4, osteoblasts to become
5. Vascular endothelial growth factor (VEGF) to
-7 bone-forming
stimulate healing at the site
cells
● From the day you started the surgery BMP’S
act as your signal GROWTH FACTORS IN HEMATOMA FORMATION
● Hematoma - most impt stage of bone healing
w/o it bone will never heal Intracartilaginous formation
● If immunocompromised, 1st stage of healing is - IGF is very very important when you produce
compromised – WALANG HEMATOMA injury in the MAXILLARY AREA (angiogenic
● Secretion of pro-inflammatory cytokines (TNF, ata?)
BMP’s, Interleukins 1, 6, 11,23) for Chondrocytes
inflammatory processes and chemotaxis - Serves as homeostasis – dapat may balance
between the 2
Increase in cellular formation
- Healing will be much faster?
Proliferate into osteoblast
Dr george s. navarra | DENT5aa 1
, BASIC DENTAL IMPLANTOLOGY
PRDM 149 | First Semester
OSSEOINTEGRATION
FIBROCARTILAGINOUS CALLUS FORMATION
(Day 5 to 11)
1. Release of VEGF leads to angiogenesis
2. Fibrin-rich granulation tissue begins to develop
3. Mesenchymal stem cells = fibroblasts,
chondroblasts, osteoblasts
4. Chondrogenesis
5. Osteoprogenitor cells
VEGF - vascular
started after hematoma clot
Once blood vessel is established
FIBROCARTILAGINOUS STAGE NA
Some parts will be chondrogenesis in the maxillary
Osteoprotegerin - induce osteoblastic formation
inducing bone tissue
Chondrogenesis will aid in the formation of new bone
tissue
NORMAL CHONDROCYTES FORMATION
Once hematom, may secretion to become
differentiated cells (chondroprogenitor) to
chrodnoblast or osteoblast the chondrocytes or
osteocyetes
DIFFERENTATION AND MATURATION
Dr george s. navarra | DENT5aa 2
