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Which of the following malignancies is associated with the skin condition shown here
(acanthosis nigricans)?
Ovarian carcinoma
Gastric carcinoma
Malignant melanoma
Multiple myeloma
Hodgkin's lymphoma ✔✔B
Acanthosis nigricans is associated with hyperpigmented areas that typically affect flexural folds
(axilla). The two basic types of acanthosis nigricans are benign and malignant. The benign form
is associated with obesity, diabetes, Stein- Leventhal syndrome, Cushing's disease, Addison's
disease, pituitary disorders, and hyperandrogenic syndromes. Drugs, including glucocorticoids,
nicotinic acid, diethylstilbestrol, and growth hormone therapy, have also caused acanthosis
nigricans. Many cases are idiopathic. Malignant acanthosis nigricans is associated with an
intestinal cancer such as gastric carcinoma.Acanthosis nigricans is associated with
hyperpigmented areas that typically affect flexural folds (axilla). The two basic types of
acanthosis nigricans are benign and malignant. The benign form is associated with obesity,
diabetes, Stein- Leventhal syndrome, Cushing's disease, Addison's disease, pituitary disorders,
and hyperandrogenic syndromes. Drugs, including glucocorticoids, nicotinic acid,
diethylstilbestrol, and growth hormone therapy, have also caused acanthosis nigricans. Many
cases are idiopathic. Malignant acanthosis nigricans is associated with an intestinal cancer such
as gastric carcinoma.
,A patient is first seen with burns to the entire right arm, the anterior right leg, and genitals. The
estimated burn surface area would be calculated as:
15%
19%
23%
27%
37% ✔✔B
The total burn surface area would be calculated as 19%: 9% for the entire right arm; 9% for the
anterior right leg (half of 18%); and 1% for the genitalia. The Rules of Nines (first degree not
included in calculation) is used to determine the extent of injury: head and neck, 9%; arm (each),
9%; trunk (anterior), 18%; trunk (posterior), 18%; leg (each), 18%; and genitalia, 1%.
A 42-year-old Native American woman presents to your office complaining of dark spots on her
face. Her medical history is unremarkable except for two previous uncomplicated pregnancies.
She is now taking oral contraceptives. The most likely diagnosis is
Solar lentigo
Melasma
Sunburn
Lupus erythematosus
Scleroderma ✔✔B
Melasma, also referred to as chloasma, is described as the "mask of pregnancy." The condition
typically affects women with dark complexions and appears as hyperpigmentation of the skin,
usually associated with the face. It is caused by long-term sun exposure, pregnancy, and oral
contraceptives. In many cases, the condition is idiopathic. Diagnosis is made clinically.
,Treatment involves the use of bleaching creams, hydroquinone, and chemical peels for more
resistant cases. In some instances, the condition disappears after pregnancy or the discontinuation
of oral contraceptives.
A patient presents with a rash, characterized by red macules and edematous papules with a
clearing center. This best describes which of the following?
erythema marginatum
erythema multiforme
varicella
impetigo ✔✔B
Target lesions, also termed iris lesions, are characteristic of erythema multiforme. The rash may
be recurrent but typically resolves over 3-6 weeks.
In a patient suspected of having seborrheic dermatitis, the most common site of involvement
would be the
upper extremities.
thighs C scalp.
D feet. ✔✔C
, The most common site of involvement of seborrheic dermatitis is the scalp. Other common sites
include the eyebrows, eyelids, nasolabial fold, and ears
A 26 year-old male complains of intense itching, especially at night and after hot showers, for the
past 4 days. On physical examination he has a few red papules and areas of excoriation on his
volar wrists, between his fingers, and around his waist. Proper diagnosis should include which of
the following tests?
KOH prep
Gram stain
Skin scraping microscopy
Tzanck prep ✔✔C
The history and exam is consistent with a scabies infection. Scrapings from the burrows should
be examined for the presence of mites, eggs, and feces.
A 35 year-old female who recently returned from a backpacking trip complains of fatigue,
malaise, fever, chills, and arthralgias. Physical examination reveals a 6 cm annular lesion with a
red border and a clear center on her mid-back. Which of the following laboratory tests would
support your diagnosis?
KOH prep of skin scrapings
Blood cultures
RAST testing
Serologic antibody testing ✔✔D