, What role does 5-HT signaling have on migraine pathophysiology?
5-HT signaling is definitely involved
- plasma 5-HT levels drop sharply during migraine
- 5-hydroxyindole acetic acid (metabolite) excretion rises during migraine
- 5-HT depletion by reserpine can induce migraine like headache
- IV 5-HT can treat migraine headache
What role does CGRP have in migraine pathophysiology?
In addition to the vascular system changes and 5-HT homeostasis, the brainstem,
trigeminal system, and release of calcitonin-gene related peptide are involved
- CGRP is an alternative splice variant of the calcitonin gene
- Main effects are vasodilation and pain transmission
The main effects of CGRP are vasodilation and pain transmission that are mediated by
what 2 receptors?
RAMP1 (Receptor activity modifying protein)
CALCRL (calcitonin receptor-like activity)
Alpha and Beta-CGRP are ___ amino acids long
37
What treatments are 5-HT1b/d agonists?
triptans, ergonovine, dihydroergotamine
Which treatments are 5-HT2 antagonists?
methysurgide
What treatment is 5-HT reuptake inhibitor?
amitriptyline
Where are the 5-HT1 receptors expressed?
5-HT signaling is definitely involved
- plasma 5-HT levels drop sharply during migraine
- 5-hydroxyindole acetic acid (metabolite) excretion rises during migraine
- 5-HT depletion by reserpine can induce migraine like headache
- IV 5-HT can treat migraine headache
What role does CGRP have in migraine pathophysiology?
In addition to the vascular system changes and 5-HT homeostasis, the brainstem,
trigeminal system, and release of calcitonin-gene related peptide are involved
- CGRP is an alternative splice variant of the calcitonin gene
- Main effects are vasodilation and pain transmission
The main effects of CGRP are vasodilation and pain transmission that are mediated by
what 2 receptors?
RAMP1 (Receptor activity modifying protein)
CALCRL (calcitonin receptor-like activity)
Alpha and Beta-CGRP are ___ amino acids long
37
What treatments are 5-HT1b/d agonists?
triptans, ergonovine, dihydroergotamine
Which treatments are 5-HT2 antagonists?
methysurgide
What treatment is 5-HT reuptake inhibitor?
amitriptyline
Where are the 5-HT1 receptors expressed?
