©GRACEAMELIA 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED
FIRST PUBLISH OCTOBER 2024
AHN 577 Infectious Disease Part 2 Study Guide
Latent TB prevention - Ans:✔✔-Isoniazid x 9 months
Latent TB with positive TB skin test or IGRA - Ans:✔✔-Rifampin daily x 4 months
Rifampin + Pyrazinamide combo use in latent TB - Ans:✔✔-Contraindicated d/t risk for severe liver injury
or death
Active TB treatment during intensive phase - Ans:✔✔-RIPE (Rifampin, Isoniazid, Pyrazinimide,
Ethambutol) x 8 weeks
Active TB treatment during continuation phase - Ans:✔✔-Isoniazid and Rifampin x 18 weeks
TB patient infectious if.. - Ans:✔✔-- Coughing
- Cavity in lung
- Sputum smears positive for AFB
- TB disease of lungs, airway, or larynx present
- Positive culture
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, ©GRACEAMELIA 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED
FIRST PUBLISH OCTOBER 2024
TB patient no longer infectious if.. - Ans:✔✔-- Symptoms improved AND
- 3 consecutive negative sputum smears AND
- Adhering to adequate treatment x 2 weeks
How do you test for HIV infection? - Ans:✔✔--- ELISA - initial screening; 99.9% sensitive
-- Western blot - > 99.99% sensitive and specific
Routine labs for treatment of HIV/AIDS - Ans:✔✔--- CD4 count - best indicator of immune fx; guides
therapy
-- HIV RNA - amt of actively replicating viruses; best indicator for diagnosing acute HIV infections; tells
about disease progression
-- CBC - detect pancytopenia
-- CMP - assess renal/hepatic function
-- Pregnancy test - prior to ARTs
-- UA to detect early nephropathy
-- Hgb A1c to assess for glucose intolerance
Typical initial regimen for HIV - Ans:✔✔-1 integrase inhibitor (or PI) + 2 NRTIs
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, ©GRACEAMELIA 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED
FIRST PUBLISH OCTOBER 2024
NRTI examples - Ans:✔✔-Tenofovir, Emtricitabine, Abacavir, Lamivudine
Common s/e of NRTIs - Ans:✔✔-- Hepatitis
- Neutropenia
- AKI
- Anemia
- Rash
- Peripheral neuropathy
- GI upset
NNRTI examples - Ans:✔✔-Efavirenz, Nevirapine
Common s/e of NNRTIs - Ans:✔✔-- Rash
- Peripheral neuropathy
- Depression
Protease inhibitor examples - Ans:✔✔-Darunavir, Cobistat
Common s/e of PIs - Ans:✔✔-- Hyperbilirubinemia
Page 3/17
FIRST PUBLISH OCTOBER 2024
AHN 577 Infectious Disease Part 2 Study Guide
Latent TB prevention - Ans:✔✔-Isoniazid x 9 months
Latent TB with positive TB skin test or IGRA - Ans:✔✔-Rifampin daily x 4 months
Rifampin + Pyrazinamide combo use in latent TB - Ans:✔✔-Contraindicated d/t risk for severe liver injury
or death
Active TB treatment during intensive phase - Ans:✔✔-RIPE (Rifampin, Isoniazid, Pyrazinimide,
Ethambutol) x 8 weeks
Active TB treatment during continuation phase - Ans:✔✔-Isoniazid and Rifampin x 18 weeks
TB patient infectious if.. - Ans:✔✔-- Coughing
- Cavity in lung
- Sputum smears positive for AFB
- TB disease of lungs, airway, or larynx present
- Positive culture
Page 1/17
, ©GRACEAMELIA 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED
FIRST PUBLISH OCTOBER 2024
TB patient no longer infectious if.. - Ans:✔✔-- Symptoms improved AND
- 3 consecutive negative sputum smears AND
- Adhering to adequate treatment x 2 weeks
How do you test for HIV infection? - Ans:✔✔--- ELISA - initial screening; 99.9% sensitive
-- Western blot - > 99.99% sensitive and specific
Routine labs for treatment of HIV/AIDS - Ans:✔✔--- CD4 count - best indicator of immune fx; guides
therapy
-- HIV RNA - amt of actively replicating viruses; best indicator for diagnosing acute HIV infections; tells
about disease progression
-- CBC - detect pancytopenia
-- CMP - assess renal/hepatic function
-- Pregnancy test - prior to ARTs
-- UA to detect early nephropathy
-- Hgb A1c to assess for glucose intolerance
Typical initial regimen for HIV - Ans:✔✔-1 integrase inhibitor (or PI) + 2 NRTIs
Page 2/17
, ©GRACEAMELIA 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED
FIRST PUBLISH OCTOBER 2024
NRTI examples - Ans:✔✔-Tenofovir, Emtricitabine, Abacavir, Lamivudine
Common s/e of NRTIs - Ans:✔✔-- Hepatitis
- Neutropenia
- AKI
- Anemia
- Rash
- Peripheral neuropathy
- GI upset
NNRTI examples - Ans:✔✔-Efavirenz, Nevirapine
Common s/e of NNRTIs - Ans:✔✔-- Rash
- Peripheral neuropathy
- Depression
Protease inhibitor examples - Ans:✔✔-Darunavir, Cobistat
Common s/e of PIs - Ans:✔✔-- Hyperbilirubinemia
Page 3/17
