©GRACEAMELIA 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED
FIRST PUBLISH OCTOBER 2024
N115 Midterm Exam Study Guide with
Complete Solutions
Preclinical studies Are done on - Ans:✔✔-animals
The intensity of a drug response is dependent on - Ans:✔✔-the site of the effect
drugs given by oral route may have a significantly higher - Ans:✔✔-first pass effect
all true - Ans:✔✔-A drug that is bound to plasma protein Is not pharmacological active.
A bound drug can be displaced from the protein by another drug
Only a free drug is filtered and excreted by glomerulus
bioavailibility - Ans:✔✔-IV=100% oral is less, the fraction of the oral dose present
cytochrome p450 - Ans:✔✔-Inducers= increased drug metabolism necessitating higher doses (decrease
half life)
Inhibitors cause the opposite so decreased drug metabolism (increase half life) so lower doses
Newer generation anticonvulsants have - Ans:✔✔-fewer adverse effects
Page 1/11
, ©GRACEAMELIA 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED
FIRST PUBLISH OCTOBER 2024
Benzodiazepines might be used in all of the following clinical situations - Ans:✔✔-a child with severe
generalized seizures
depressed patient with insomnia and nightmares
sedation of patient for minor plastic surgery in office (not parkinsons)
Adverse effects of selective serotonin reuptake inhibitors (SSRI's) - Ans:✔✔-sedation
increased blood glucose, metabolic syndrome
increased libido
a patient taking lithium for bipolar disorder, the nurse must be aware of - Ans:✔✔-Effectiveness takes 1-
3 weeks, Hand tremor may occur at therapeutic doses, Compliance must be considered, Monitoring
blood levels is important
three most important properties of an ideal drug - Ans:✔✔-effectiveness, safety and selectivity
pharmacokinetics - Ans:✔✔-Site of adminstration to circulation and absorption. movement of the drug
through the body
The following antimicrobials is/are effective against community acquired MRSA - Ans:✔✔-Cefaroline
(Teflaro)
Vancomycin
Page 2/11
FIRST PUBLISH OCTOBER 2024
N115 Midterm Exam Study Guide with
Complete Solutions
Preclinical studies Are done on - Ans:✔✔-animals
The intensity of a drug response is dependent on - Ans:✔✔-the site of the effect
drugs given by oral route may have a significantly higher - Ans:✔✔-first pass effect
all true - Ans:✔✔-A drug that is bound to plasma protein Is not pharmacological active.
A bound drug can be displaced from the protein by another drug
Only a free drug is filtered and excreted by glomerulus
bioavailibility - Ans:✔✔-IV=100% oral is less, the fraction of the oral dose present
cytochrome p450 - Ans:✔✔-Inducers= increased drug metabolism necessitating higher doses (decrease
half life)
Inhibitors cause the opposite so decreased drug metabolism (increase half life) so lower doses
Newer generation anticonvulsants have - Ans:✔✔-fewer adverse effects
Page 1/11
, ©GRACEAMELIA 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED
FIRST PUBLISH OCTOBER 2024
Benzodiazepines might be used in all of the following clinical situations - Ans:✔✔-a child with severe
generalized seizures
depressed patient with insomnia and nightmares
sedation of patient for minor plastic surgery in office (not parkinsons)
Adverse effects of selective serotonin reuptake inhibitors (SSRI's) - Ans:✔✔-sedation
increased blood glucose, metabolic syndrome
increased libido
a patient taking lithium for bipolar disorder, the nurse must be aware of - Ans:✔✔-Effectiveness takes 1-
3 weeks, Hand tremor may occur at therapeutic doses, Compliance must be considered, Monitoring
blood levels is important
three most important properties of an ideal drug - Ans:✔✔-effectiveness, safety and selectivity
pharmacokinetics - Ans:✔✔-Site of adminstration to circulation and absorption. movement of the drug
through the body
The following antimicrobials is/are effective against community acquired MRSA - Ans:✔✔-Cefaroline
(Teflaro)
Vancomycin
Page 2/11
