©GRACEAMELIA 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED
FIRST PUBLISH OCTOBER 2024
N115 Midterm Study Questions and
Answers
Which of the following does NOT influence the degree to which a drug moves by passive diffusion across
membranes?
a. the lipophilicity of a drug
b. the degree of gastric absorption
c. the proportion of drug that is charged
d. the concentration gradient between the two compartments - Ans:✔✔-ANS: B
Which of the following characteristics of a drug in a solution contributes to its passive diffusion through
membranes (choose all that apply)?
a. high lipophilicity
b. its positive ionic charge
c. high hydrophilicity
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d. small molecular size - Ans:✔✔-ANS: A, D
Penetration of high molecular weight drugs through membranes is most dependent on which of the
following processes?
a. phagocytosis
b. active transport
c. passive diffusion
d. enzyme inhibition - Ans:✔✔-ANS: B
Which one of the following is a true statement with regard to pH-dependent ionization?
a. Acids ionize best in an acidic medium.
b. For bases to ionize, the medium must be acidic.
c. An acid is a proton acceptor, whereas a base is a proton donor.
d. When an acid gives up positively charged ions, the acid becomes more basic. - Ans:✔✔-ANS: B
Based on body compartment pH, a weak acid such as acetaminophen (Tylenol) or ampicillin (Amoxil) will
be absorbed best at which one of the following sites?
a. lung
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FIRST PUBLISH OCTOBER 2024
b. stomach (pH ~ 2)
c. subcutaneous fat
d. small intestine (pH ~ 5.5 -7.5) - Ans:✔✔-ANS: B
Which of the following would be better absorbed by means of an intramuscular (IM) injection?
a. water soluble drug
b. protein bound drug
c. lipid soluble drug
d. drugs metabolized by first pass processes - Ans:✔✔-ANS: A
Which of the following is true regarding a drug that binds extensively to plasma proteins?
a. is readily eliminated by the kidney
b. only unbound drug exits the vasculature
c. has a shorter half-life than a weakly bound drug
d. is likely to have few drug interactions with drugs that are also extensively bound
to plasma proteins. - Ans:✔✔-ANS: A
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FIRST PUBLISH OCTOBER 2024
A drug that is highly extracted by the liver (hepatic first pass effect) will have which one of the following?
a. long half-life (t1/2)
b. low renal clearance
c. low oral bioavailability
d. high volume of distribution (Vd) - Ans:✔✔-ANS: C
Genetic differences in drug CYP450 enzymes may lead to all of the following except:
a. increased adverse effects
b. increased drug toxicity
c. increased drug interactions
d. increased rate of absorption in the gut - Ans:✔✔-ANS: D
Why are polar groups added to lipid soluble drugs by hepatic enzymes during Phase I and Phase II
reactions?
a. to produce slower absorption and a longer half-life
b. to increase the concentration in the plasma compartment after oral administration
c. to prevent passive reabsorption and promote renal elimination
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FIRST PUBLISH OCTOBER 2024
N115 Midterm Study Questions and
Answers
Which of the following does NOT influence the degree to which a drug moves by passive diffusion across
membranes?
a. the lipophilicity of a drug
b. the degree of gastric absorption
c. the proportion of drug that is charged
d. the concentration gradient between the two compartments - Ans:✔✔-ANS: B
Which of the following characteristics of a drug in a solution contributes to its passive diffusion through
membranes (choose all that apply)?
a. high lipophilicity
b. its positive ionic charge
c. high hydrophilicity
Page 1/69
, ©GRACEAMELIA 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED
FIRST PUBLISH OCTOBER 2024
d. small molecular size - Ans:✔✔-ANS: A, D
Penetration of high molecular weight drugs through membranes is most dependent on which of the
following processes?
a. phagocytosis
b. active transport
c. passive diffusion
d. enzyme inhibition - Ans:✔✔-ANS: B
Which one of the following is a true statement with regard to pH-dependent ionization?
a. Acids ionize best in an acidic medium.
b. For bases to ionize, the medium must be acidic.
c. An acid is a proton acceptor, whereas a base is a proton donor.
d. When an acid gives up positively charged ions, the acid becomes more basic. - Ans:✔✔-ANS: B
Based on body compartment pH, a weak acid such as acetaminophen (Tylenol) or ampicillin (Amoxil) will
be absorbed best at which one of the following sites?
a. lung
Page 2/69
, ©GRACEAMELIA 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED
FIRST PUBLISH OCTOBER 2024
b. stomach (pH ~ 2)
c. subcutaneous fat
d. small intestine (pH ~ 5.5 -7.5) - Ans:✔✔-ANS: B
Which of the following would be better absorbed by means of an intramuscular (IM) injection?
a. water soluble drug
b. protein bound drug
c. lipid soluble drug
d. drugs metabolized by first pass processes - Ans:✔✔-ANS: A
Which of the following is true regarding a drug that binds extensively to plasma proteins?
a. is readily eliminated by the kidney
b. only unbound drug exits the vasculature
c. has a shorter half-life than a weakly bound drug
d. is likely to have few drug interactions with drugs that are also extensively bound
to plasma proteins. - Ans:✔✔-ANS: A
Page 3/69
, ©GRACEAMELIA 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED
FIRST PUBLISH OCTOBER 2024
A drug that is highly extracted by the liver (hepatic first pass effect) will have which one of the following?
a. long half-life (t1/2)
b. low renal clearance
c. low oral bioavailability
d. high volume of distribution (Vd) - Ans:✔✔-ANS: C
Genetic differences in drug CYP450 enzymes may lead to all of the following except:
a. increased adverse effects
b. increased drug toxicity
c. increased drug interactions
d. increased rate of absorption in the gut - Ans:✔✔-ANS: D
Why are polar groups added to lipid soluble drugs by hepatic enzymes during Phase I and Phase II
reactions?
a. to produce slower absorption and a longer half-life
b. to increase the concentration in the plasma compartment after oral administration
c. to prevent passive reabsorption and promote renal elimination
Page 4/69
