©GRACEAMELIA 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED
FIRST PUBLISH OCTOBER 2024
N115 TAKE HOME MIDTERM EXAM
STUDY QUESTIONS AND ANSWERS
Which one of the following is not a major feature of an ideal drug?
a. demonstrated effectiveness
b. covalent interaction with receptor
c. receptor selectivity
d. no adverse effects - Ans:✔✔-ANS: B
Variability of drug response in an individual patient may be introduced by which of the following:
1. genetic differences in drug metabolism
2. covalent interaction with receptor
3. poor compliance and missed doses
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, ©GRACEAMELIA 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED
FIRST PUBLISH OCTOBER 2024
4. inadequate record keeping
a. 1 and 2
b. 1 and 3
c. 1,3,4
d. all of the above - Ans:✔✔-ANS: B
Large multi-site clinical trials, usually with thousands of subjects, are conducted in which phase of drug
evaluation prior to FDA approval?
a. Preclinical drug screening
b. Phase 1
c. Phase 2
d. Phase 3 - Ans:✔✔-ANS: D
Which one of the following is the ultimate factor that determines the intensity of drug response?
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, ©GRACEAMELIA 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED
FIRST PUBLISH OCTOBER 2024
1. cellular location of the receptor [intra vs. extracellular]
2. drug concentration at receptor site
3. proportion of nonionized activity to ionized activity
4. prescribed dose
a. 1 only
b. 2 only
c. 1,2,4
d. all of the above - Ans:✔✔-ANS: B
Which of the following pharmacokinetics term describes how drugs move from the site of administration
to the circulation?
a. Absorption
b. Distribution
c. Metabolism
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, ©GRACEAMELIA 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED
FIRST PUBLISH OCTOBER 2024
d. Excretion - Ans:✔✔-ANS: A
Which of the following is true regarding a drug that binds extensively to plasma proteins?
a. will likely have a large volume of distribution [Vd]
b. will be readily eliminated by the kidney
c. is unlikely to affect the bioavailability of other drugs
d. only unbound drug is available for distribution - Ans:✔✔-ANS: D
Acidification of the urine by high doses of Vitamin C [ascorbic acid] may result in:
a. better elimination of meperidine [Demerol], a basic drug, due to ion trapping
b. better elimination of aspirin, an acidic drug, due to ion trapping
c. altered concentration gradient and faster absorption of meperidine [Demerol], a basic drug
d. altered concentration gradient and faster absorption of aspirin, an acidic drug - Ans:✔✔-ANS: A
Which of the following does NOT influence the degree to which a drug moves by passive diffusion?
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FIRST PUBLISH OCTOBER 2024
N115 TAKE HOME MIDTERM EXAM
STUDY QUESTIONS AND ANSWERS
Which one of the following is not a major feature of an ideal drug?
a. demonstrated effectiveness
b. covalent interaction with receptor
c. receptor selectivity
d. no adverse effects - Ans:✔✔-ANS: B
Variability of drug response in an individual patient may be introduced by which of the following:
1. genetic differences in drug metabolism
2. covalent interaction with receptor
3. poor compliance and missed doses
Page 1/46
, ©GRACEAMELIA 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED
FIRST PUBLISH OCTOBER 2024
4. inadequate record keeping
a. 1 and 2
b. 1 and 3
c. 1,3,4
d. all of the above - Ans:✔✔-ANS: B
Large multi-site clinical trials, usually with thousands of subjects, are conducted in which phase of drug
evaluation prior to FDA approval?
a. Preclinical drug screening
b. Phase 1
c. Phase 2
d. Phase 3 - Ans:✔✔-ANS: D
Which one of the following is the ultimate factor that determines the intensity of drug response?
Page 2/46
, ©GRACEAMELIA 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED
FIRST PUBLISH OCTOBER 2024
1. cellular location of the receptor [intra vs. extracellular]
2. drug concentration at receptor site
3. proportion of nonionized activity to ionized activity
4. prescribed dose
a. 1 only
b. 2 only
c. 1,2,4
d. all of the above - Ans:✔✔-ANS: B
Which of the following pharmacokinetics term describes how drugs move from the site of administration
to the circulation?
a. Absorption
b. Distribution
c. Metabolism
Page 3/46
, ©GRACEAMELIA 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED
FIRST PUBLISH OCTOBER 2024
d. Excretion - Ans:✔✔-ANS: A
Which of the following is true regarding a drug that binds extensively to plasma proteins?
a. will likely have a large volume of distribution [Vd]
b. will be readily eliminated by the kidney
c. is unlikely to affect the bioavailability of other drugs
d. only unbound drug is available for distribution - Ans:✔✔-ANS: D
Acidification of the urine by high doses of Vitamin C [ascorbic acid] may result in:
a. better elimination of meperidine [Demerol], a basic drug, due to ion trapping
b. better elimination of aspirin, an acidic drug, due to ion trapping
c. altered concentration gradient and faster absorption of meperidine [Demerol], a basic drug
d. altered concentration gradient and faster absorption of aspirin, an acidic drug - Ans:✔✔-ANS: A
Which of the following does NOT influence the degree to which a drug moves by passive diffusion?
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