NURS 4600 Week 3 Exam Study Guide Solutions

NURS 4600 Week 3 Exam Study Guide Solutions IMMUNIZATIONS - Ans:-IMMUNIZATIONS active vs passive immunity - Ans:-Active = individual has memory cells - can make their own antibodies & provides long term immunity Passive = person given antibodies, these work then die, no long term immunity, no memory cells. attenuated - Ans:-weakened, thinned, decreased toxoids - Ans:-inactivated exotoxins used in vaccines. usually boosters required Where are the most common thrombosis locations? - Ans:-legs, lungs, heart, brain IVIG - Ans:-intravenous immunoglobulin. ppl get them once a month side effects of immunoglobulins - Ans:-thrombosis contraindications for immunization use - Ans:-During febrile illnesses During immunosuppressive drug therapy ©GRACEAMELIA 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED FIRST PUBLISH OCTOBER 2024 Page 2/18 During immunodeficient states Leukemia Lymphoma Generalized malignancy Pregnancy ACIP - Ans:-CDC Advisory Committee on Immunization Practices What are the sources of information on immunizations? - Ans:-CDC ACIP American Academy of Pediatrics (AAP) American Academy of Family Physicians (AAFP) Local health department mild vs serious reactions for vaccines - Ans:-Mild rxn - arm soreness, fever, cold symptoms Serious rxn - allergic rxn via anaphylaxis, pruritus, obscure GI symptoms via vomiting and diarrhea GVHD - Ans:-graft-versus-host disease complication that occurs following a stem cell or bone marrow transplant in which the transplant produces antibodies against recipient's organs that can be severe enough to cause death ©GRACEAMELIA 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED FIRST PUBLISH OCTOBER 2024 Page 3/18 Acute organ rejection - Ans:-- Immediate failure of that organ - Flu-like symptoms (fever, chills, malaise) - Immediate biopsy of the transplanted organ is usually warranted as soon as possible. What lab values will you look at for organ transplant? - Ans:-WBC less than 5k means immunosupressed Liver is AST and ALT Kidney is creatinine and BUN vasculitis lesion - Ans:-intense inflammation, vessel wall necrosis chronic reaction to organ transplant - Ans:-Occur after months or years of normal function Characteristics include Progressive failure of transplanted organ Fibrosis of blood vessels Mycophenolate mofetil - Ans:-CellCept brand name ©GRACEAMELIA 2024/2025 ACADEMIC YEAR. ALL RIGHTS RESERVED FIRST PUBLISH OCTOBER 2024 Page 4/18 Acts in B and T cells to inhibit inosine monophosphate (IMP) dehydrogenase--decreased GMP in de novo purine synth--decreased DNA synth in B and T cells--decreased prolif of B and T cells Use = immunosuppressant in transplant pts, also for autoimmune disorders Cyclosporine MOA - Ans:-Restasis brand name inhibits both cellular and humoral immunity affect t lymphocytes more than b lymphocytes Nephrotoxic, hirsutism, hypertension and hyperlipidemia Malignancies - skin, lymphomas, and solid or