NURS 5463 - Mod 3 - Platelet Disorders Latest
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ADAMTS13 in TTP - CORRECT ANSWER: Severe deficiency < 10% confirms
diagnosis
Low level (10-60%) - occurs in sepsis, malignancy & those w/ TTP who receive many
transfusions)
Normal >60% - TTP unlikely
(Test not necessarily reliable, don't wait for results to initiate treatment)
Anticoagulant proteins - CORRECT ANSWER: antithrombin and tissue factor pathway
inhibitor
Causes of Thrombocytopenia - CORRECT ANSWER: -hemodilution (occurs post op,
drop in 20-70%, usually nadir in 2-4 days)
-Hypersplenism (platelets destroyed in the spleen)
-HIV
-Viral infections
-SLE
Chronic IT Therapy - CORRECT ANSWER: Managed by hematology
Splenectomy
Immune suppression with Rituximab
For those who want to avoid splenectomy & Rituximab - Rominplostim & Fostamatinib
, Coagulation proteins - CORRECT ANSWER: Fibrinogen, Factor V, VII, VIII, IX, XIII, high
molecular weight kininogen, prekallikrein
Conjugated Estrogen - CORRECT ANSWER: controls more chronic bleeding
IV, PO or transdermal
0.6mg/kg daily for 5 days
effects seen in 1st day and peak at 5-7 days, lasts a week or more after dc
Correcting Anemia r/t Uremic Bleeding - CORRECT ANSWER: Growth factors or
transfusions if acutely bleeding
Give PRBC to keep HCT at 30%
1 unit PRBCs will raise H/H by 1G or 3%
Desmopressin (dDAVP) - CORRECT ANSWER: IV or SC
- Increases levels of Factor VIII and von Willebrand factor
- Improvement seen within 1 hour and lasts up to 4-8 hours
- Max effect reached in 1-2 doses
- Watch for hyponatremia and water intoxication
Drugs that Ti Thrombocytopenia - CORRECT ANSWER: Sulfonamides
Quinine (tonic water)
Heparin
Eptifibatide (Integrillin)
Rifampin (Rifadin)
Beta lactam antibiotics (PCN, Cephalosporins)
Carbamazepine (Tegretol)
Levofloxacin (flouroquinolones)
Vancomycin
Linezolid (Zyvox)
Update 2024-2025 Actual Exam from Credible
Sources with Questions and Verified Correct
Answers Golden Ticket to Guaranteed A+
Verified by Professor
ADAMTS13 in TTP - CORRECT ANSWER: Severe deficiency < 10% confirms
diagnosis
Low level (10-60%) - occurs in sepsis, malignancy & those w/ TTP who receive many
transfusions)
Normal >60% - TTP unlikely
(Test not necessarily reliable, don't wait for results to initiate treatment)
Anticoagulant proteins - CORRECT ANSWER: antithrombin and tissue factor pathway
inhibitor
Causes of Thrombocytopenia - CORRECT ANSWER: -hemodilution (occurs post op,
drop in 20-70%, usually nadir in 2-4 days)
-Hypersplenism (platelets destroyed in the spleen)
-HIV
-Viral infections
-SLE
Chronic IT Therapy - CORRECT ANSWER: Managed by hematology
Splenectomy
Immune suppression with Rituximab
For those who want to avoid splenectomy & Rituximab - Rominplostim & Fostamatinib
, Coagulation proteins - CORRECT ANSWER: Fibrinogen, Factor V, VII, VIII, IX, XIII, high
molecular weight kininogen, prekallikrein
Conjugated Estrogen - CORRECT ANSWER: controls more chronic bleeding
IV, PO or transdermal
0.6mg/kg daily for 5 days
effects seen in 1st day and peak at 5-7 days, lasts a week or more after dc
Correcting Anemia r/t Uremic Bleeding - CORRECT ANSWER: Growth factors or
transfusions if acutely bleeding
Give PRBC to keep HCT at 30%
1 unit PRBCs will raise H/H by 1G or 3%
Desmopressin (dDAVP) - CORRECT ANSWER: IV or SC
- Increases levels of Factor VIII and von Willebrand factor
- Improvement seen within 1 hour and lasts up to 4-8 hours
- Max effect reached in 1-2 doses
- Watch for hyponatremia and water intoxication
Drugs that Ti Thrombocytopenia - CORRECT ANSWER: Sulfonamides
Quinine (tonic water)
Heparin
Eptifibatide (Integrillin)
Rifampin (Rifadin)
Beta lactam antibiotics (PCN, Cephalosporins)
Carbamazepine (Tegretol)
Levofloxacin (flouroquinolones)
Vancomycin
Linezolid (Zyvox)
