Sherpath Pharmacokinetics 2024

Sherpath Pharmacokinetics 2024 Drugs must be given with the most appropriate route, dosage, and timing. Why is this important? - answer-To achieve a balance between high enough drug concentrations to be effective and to minimize the risk to the patient. The nurse understands that drugs are given with the most appropriate route, dosage, and timing to achieve a balance between high enough drug concentrations to be effective and to minimized the risk to the patient. How can the first-pass effect typically be avoided? - answer-Administer medication parenterally A medication with a first-pass effect should be administered parenterally to avoid inactivation on its first pass through the liver. Why do older adult patients sometimes require reduced doses of medications? - answer-Some older adult patients have a decreased ability to metabolize drugs, which can lead to drug toxicity. Older adult patients sometimes require reduced doses of medications because of a decreased ability to metabolize drugs, which can lead to drug toxicity. How can a prodrug be effective as a medication? - answer-A prodrug is inactive when administered and, through metabolism, undergoes conversion to an active form. A prodrug is an inactive medication that must go through metabolism to be converted to an active form. How does drug metabolism take place in the liver? - answer-The hepatic microsomal enzymes break down drugs into metabolites. The liver contains hepatic microsomal enzymes, which metabolize or break down drugs. Why are medications with a narrow therapeutic range difficult to administer safely? - answer-They have little margin between therapeutic and toxic plasma concentrations.