Sherpath Pharmacodynamics 2024

Sherpath Pharmacodynamics 2024 If a patient receives an average effective dose (ED₅₀) at initial treatment and shows signs of toxicity, which action by the health care provider should the nurse anticipate? - answer-Reduce the dosage. The ED50 is defined as the dose that is required to produce a defined therapeutic response in 50% of the population. Patients who show signs of toxicity will need a dosage reduction. The patient read that a new medication has a high therapeutic index, and asks the nurse what that means. How should the nurse respond? - answer-"A high therapeutic index indicates that a drug is relatively safe." The therapeutic index is a measure of a drug's safety. A large (or high) therapeutic index indicates that a drug is relatively safe. Conversely, a small (or low) therapeutic index indicates that a drug is relatively unsafe. Why is it difficult to predict how each individual patient will respond to a medication? - answerTherapeutic response can vary between patients due to interpatient variability. The dose required to produce a therapeutic response can vary substantially from patient to patient, because people differ from one another. Because of interpatient variation, it is not possible to predict exactly how an individual patient will respond to medication. Hence, each patient must be evaluated to determine his or her actual response. How is duration of action defined? - answer-The length of time the drug exerts a therapeutic effect. Duration of action is defined as the length of time the drug exerts a therapeutic effect. Which statement by the nurse indicates understanding regarding medication with high potency? - answer-"This medication will produce a significant therapeutic response at a low dose." A potent drug is simply a drug that produces its effects at low doses. A drug's affinity to its receptor is most closely associated with which characteristic of the drug? - answerPotency