Maryville Pharm NURS 615 Exam 1 with
complete solutions
what the drug does to the body - ** VERIFIED ANSWERS **✔✔Pharmacodynamics
what the body does to the drug (absorption, distribution, metabolism, excretion) - ** VERIFIED
ANSWERS **✔✔pharmacokinetics
how is the drug entered into the body? - ** VERIFIED ANSWERS **✔✔absorption
which substance is most likely to be absorbed in the intestines rather than in the stomach? - **
VERIFIED ANSWERS **✔✔sodium bicarb
what happens to drugs if there is kidney insufficency - ** VERIFIED ANSWERS **✔✔they are not
eliminated properly. There can be a build up which can cause a stronger effect, longer effect, and
toxicity
what does absorption of a drug depend on? - ** VERIFIED ANSWERS **✔✔membrane penetration,
lipid solubility, and ionization (which depends on pH)
drugs that are ionized are ____ - ** VERIFIED ANSWERS **✔✔hydrophilic
drugs that are unionized are ____ - ** VERIFIED ANSWERS **✔✔lipophilic
___philic drugs absorb easily across membranes - ** VERIFIED ANSWERS **✔✔lipophilic
membrane penetration, how things diffuse across - ** VERIFIED ANSWERS **✔✔distribution
Lipophilic drugs typically go through membranes _____ - ** VERIFIED ANSWERS **✔✔passively
, drugs that are protein bound require a certain amount of ___ in the blood - ** VERIFIED ANSWERS
**✔✔albumin
drugs are not ___ when they are bound to proteins - ** VERIFIED ANSWERS **✔✔active
only unbound/free drugs can ___ - ** VERIFIED ANSWERS **✔✔act
what is first pass effect - ** VERIFIED ANSWERS **✔✔when drugs are taken orally they must first
pass through the liver and then be metabolized; whatever is left after metabolism is sent on to
circulation
Not enough albumin or impaired kidney/liver function can cause? - ** VERIFIED ANSWERS
**✔✔drug toxicity
what does distribution depend on - ** VERIFIED ANSWERS **✔✔the type of tissue the drug needs
to distribute to for its actions
these kinds of drugs have a very low volume of distribution because they tend to roam freely in the
circulation and are cleared by the kidneys - ** VERIFIED ANSWERS **✔✔hydrophilic
these drugs have a high volume of distribution are a cleared by the liver with high intracellular and
tissue penetration - ** VERIFIED ANSWERS **✔✔lipophilic
___ has an effect on lipophilic drugs so they should be given using total body weight - ** VERIFIED
ANSWERS **✔✔obesity
hydrophilic drugs should be dosed using _______ - ** VERIFIED ANSWERS **✔✔adjusted/ideal
body weight
which kinds of drugs are more apt to cross the BBB and placenta? why? - ** VERIFIED ANSWERS
**✔✔lipophilic; smaller and typically unionized
complete solutions
what the drug does to the body - ** VERIFIED ANSWERS **✔✔Pharmacodynamics
what the body does to the drug (absorption, distribution, metabolism, excretion) - ** VERIFIED
ANSWERS **✔✔pharmacokinetics
how is the drug entered into the body? - ** VERIFIED ANSWERS **✔✔absorption
which substance is most likely to be absorbed in the intestines rather than in the stomach? - **
VERIFIED ANSWERS **✔✔sodium bicarb
what happens to drugs if there is kidney insufficency - ** VERIFIED ANSWERS **✔✔they are not
eliminated properly. There can be a build up which can cause a stronger effect, longer effect, and
toxicity
what does absorption of a drug depend on? - ** VERIFIED ANSWERS **✔✔membrane penetration,
lipid solubility, and ionization (which depends on pH)
drugs that are ionized are ____ - ** VERIFIED ANSWERS **✔✔hydrophilic
drugs that are unionized are ____ - ** VERIFIED ANSWERS **✔✔lipophilic
___philic drugs absorb easily across membranes - ** VERIFIED ANSWERS **✔✔lipophilic
membrane penetration, how things diffuse across - ** VERIFIED ANSWERS **✔✔distribution
Lipophilic drugs typically go through membranes _____ - ** VERIFIED ANSWERS **✔✔passively
, drugs that are protein bound require a certain amount of ___ in the blood - ** VERIFIED ANSWERS
**✔✔albumin
drugs are not ___ when they are bound to proteins - ** VERIFIED ANSWERS **✔✔active
only unbound/free drugs can ___ - ** VERIFIED ANSWERS **✔✔act
what is first pass effect - ** VERIFIED ANSWERS **✔✔when drugs are taken orally they must first
pass through the liver and then be metabolized; whatever is left after metabolism is sent on to
circulation
Not enough albumin or impaired kidney/liver function can cause? - ** VERIFIED ANSWERS
**✔✔drug toxicity
what does distribution depend on - ** VERIFIED ANSWERS **✔✔the type of tissue the drug needs
to distribute to for its actions
these kinds of drugs have a very low volume of distribution because they tend to roam freely in the
circulation and are cleared by the kidneys - ** VERIFIED ANSWERS **✔✔hydrophilic
these drugs have a high volume of distribution are a cleared by the liver with high intracellular and
tissue penetration - ** VERIFIED ANSWERS **✔✔lipophilic
___ has an effect on lipophilic drugs so they should be given using total body weight - ** VERIFIED
ANSWERS **✔✔obesity
hydrophilic drugs should be dosed using _______ - ** VERIFIED ANSWERS **✔✔adjusted/ideal
body weight
which kinds of drugs are more apt to cross the BBB and placenta? why? - ** VERIFIED ANSWERS
**✔✔lipophilic; smaller and typically unionized
