Immunology Block 2 Exam 2024

Immunology Block 2 Exam 2024 _______ greatly activates the classical pathway of complement activation - answer-IgM _______ is expressed by T cells whose function is to activate other cells. - answer-CD4 ___________ is expressed by cytotoxic T cells - answer-CD8 ____________ molecules present peptides from pathogens, commonly viruses, to CD8 T cells, which are specialized to kill any cell that they specifically recognize. - answer-MHC class I _____________ increases the expression of both MHC Class I and MHC Class II molecules, and can induce the expression of MHC Class II molecules on certain cell types that do not normally express them - answer-IFN-Gamma ______________ dendritic cells are thought to act as sentinels in early defense against viral infection on the basis of their expression of TLRs and the intracellular nucleic acid-sensing RIG-I-like helicases, and their high production of antiviral type I interferons. - answer-Plasmacytoid A mutagenesis screen performed on mice identified a gene with an important function in B cells. Analysis of B cells from the spleens of these mutant mice showed the results shown in Figure Q5.23A. However, when the C coding sequences were determined, no mutations in these DNA sequences were found. To study this further, genetic crosses were set-up with another mouse strain carrying an allelic variant of the immunoglobulin heavy chain locus. The original mutant mouse strain (strain A) carries IgMa and IgDa alleles of these heavy chain genes. The second mouse strain (strain B) carries the IgMb and IgDb alleles of the heavy chain genes. These two parental strains were crossed together, generating progeny that were all heterozygous for IgM and IgD alleles (i.e., all progeny are IgMa/b and IgDa/b). These heterozygous progeny represent the F1 generation. Brother/sister matings of F1 mice generate F2 progeny. These F2 mice - answer-The gene for a factor required for alternative mRNA splicing of the immunoglobulin heavy chain primary mRNA transcript