Dermatology
Skin function:
• UV protection
• Mechanical functions
• Thermoregulation (sweat glands, blood vessel constriction/dilation)
• Chemical factor protection
• Microorganism protection
• Protection from water and ion escape
• Vitamin D synthesis
• SIS (skin immune system)
• SALT (skin associated lymphoid tissue)
SIS UV Pilosebaceus unit
T-cells - Th1 & Th2 Photoaging sebaceus gland
Mast cells - histamine tumors hair follicle
B-cells Immunosuppression papilla
Photodermatosis - prokoved by
Neutrophils UV hair shaft
Eosinophils M. erector pili
langerhans cells - search for
antigens
Cornified layer – pH 5.5desmosomes, corneocytes and lipids in layers
Granular layer – apoptosis, final process, dense structure of keratin
Spinous layer – produce keratin and differentiate
Basal membrane – some patients produce antibodies against basal membrane
Basal layer – cell producing layer, takes 30 days to travel to surface
Papillary layer – bed for epidermis, papillary plexus
Reticular layer – collagen fibers 1&2, elastic fibers and reticular fibers
Primary lesions:
1
Skin function:
• UV protection
• Mechanical functions
• Thermoregulation (sweat glands, blood vessel constriction/dilation)
• Chemical factor protection
• Microorganism protection
• Protection from water and ion escape
• Vitamin D synthesis
• SIS (skin immune system)
• SALT (skin associated lymphoid tissue)
SIS UV Pilosebaceus unit
T-cells - Th1 & Th2 Photoaging sebaceus gland
Mast cells - histamine tumors hair follicle
B-cells Immunosuppression papilla
Photodermatosis - prokoved by
Neutrophils UV hair shaft
Eosinophils M. erector pili
langerhans cells - search for
antigens
Cornified layer – pH 5.5desmosomes, corneocytes and lipids in layers
Granular layer – apoptosis, final process, dense structure of keratin
Spinous layer – produce keratin and differentiate
Basal membrane – some patients produce antibodies against basal membrane
Basal layer – cell producing layer, takes 30 days to travel to surface
Papillary layer – bed for epidermis, papillary plexus
Reticular layer – collagen fibers 1&2, elastic fibers and reticular fibers
Primary lesions:
1
