NR507 MIDTERM EXAM ANSWERS
AND THEIR EXPECTED QUESTIONS
Allergic reaction
What is a type 1 hypersensitivity reaction?
IgE
What is a type 1 hypersensitivity reaction mediated by?
mast cell degranulation
What causes inflammation in a type 1 hypersensitivity
reaction?
Itching, rash
What are local symptoms of a type one hypersensitivity
reaction?
Wheezing
What is a systemic symptom of a type 1 hypersensitivity
reaction?
anaphylactic reaction-systemic response-
hypotension, severe bronchoconstriction
What is the most danger form of a type 1 hypersensitivity
reaction?
Epinephrine
What is the main treatment of a type 1 hypersensitivity
reaction?
Cytotoxic reaction; tissue specific
What is a type 2 hypersensitivity reaction?
Macrophages
What are the primary effector cells involved in a type 2
hypersensitivity reaction?
, True
True or false: Type 2 hypersensitivity reactions can cause
tissue damage or alter function
Type 2- Grave's disease alters thyroid function, but
does not destroy thyroid tissues
What type of hypersensitivity reaction is Grave's disease?
(hyperthyroidism)
Type 2- cell/tissue damage occurs; during severe
transfusion reactions, the transfused erythrocytes are
destroyed by agglutination or complement-mediated
lysis
What type of hypersensitivity reaction is an incompatible
blood type?
Type 2 is organ specific
Between type 2 and type 3, which reaction is organ-
specific?
Type 3. Type 2 binds the antibody to the antigen on
the cell surface
Between type 2 and type 3 reactions, which involved the
antibody binding to a soluble antigen outside the cells
surface that is released into the blood or body fluids, then
deposited into the tissues?
Type 3: arthritis-antigen/antibodies are deposited in
the joints
What type of hypersensitivity reaction is rheumatoid
arthritis?
Type 3: very closely related to
autoimmunity-antigen/antibodies deposit in organs
that cause tissue damage
What type of hypersensitivity reaction is systemic lupus
erythematous (SLE)?
AND THEIR EXPECTED QUESTIONS
Allergic reaction
What is a type 1 hypersensitivity reaction?
IgE
What is a type 1 hypersensitivity reaction mediated by?
mast cell degranulation
What causes inflammation in a type 1 hypersensitivity
reaction?
Itching, rash
What are local symptoms of a type one hypersensitivity
reaction?
Wheezing
What is a systemic symptom of a type 1 hypersensitivity
reaction?
anaphylactic reaction-systemic response-
hypotension, severe bronchoconstriction
What is the most danger form of a type 1 hypersensitivity
reaction?
Epinephrine
What is the main treatment of a type 1 hypersensitivity
reaction?
Cytotoxic reaction; tissue specific
What is a type 2 hypersensitivity reaction?
Macrophages
What are the primary effector cells involved in a type 2
hypersensitivity reaction?
, True
True or false: Type 2 hypersensitivity reactions can cause
tissue damage or alter function
Type 2- Grave's disease alters thyroid function, but
does not destroy thyroid tissues
What type of hypersensitivity reaction is Grave's disease?
(hyperthyroidism)
Type 2- cell/tissue damage occurs; during severe
transfusion reactions, the transfused erythrocytes are
destroyed by agglutination or complement-mediated
lysis
What type of hypersensitivity reaction is an incompatible
blood type?
Type 2 is organ specific
Between type 2 and type 3, which reaction is organ-
specific?
Type 3. Type 2 binds the antibody to the antigen on
the cell surface
Between type 2 and type 3 reactions, which involved the
antibody binding to a soluble antigen outside the cells
surface that is released into the blood or body fluids, then
deposited into the tissues?
Type 3: arthritis-antigen/antibodies are deposited in
the joints
What type of hypersensitivity reaction is rheumatoid
arthritis?
Type 3: very closely related to
autoimmunity-antigen/antibodies deposit in organs
that cause tissue damage
What type of hypersensitivity reaction is systemic lupus
erythematous (SLE)?
