CASE STUDY QUESTIONS: GENETIC CODE EXAM QUESTIONS
WITH VERIFIED SOLUTIONS GRADED A++
Why would someone with this type of mutation be at a much higher risk for
overdosing on a prescribed drug?
When a drug is prescribed, it is prescribed at a dose that assumes that the person's
body would be metabolizing (breaking down) the drug at a specific rate. If the person
lacks the enzymes (or enzyme functions) that are responsible for this metabolism, a
"normal" dose can become an "overdose" because the drug does not break down. In
addition, if the drug is prescribed as "multiple" or "daily" doses, the problem can become
amplified because new doses are being applied before the previous dose has been
removed from the body.
The underlying problem in this case resides in Henry's "genes." From what you
know about the function of a gene, explain how this problem led to a malfunction
in one of Henry's proteins (the CYP2C9 enzyme).
Gene is like a map for the cell to use when creating other molecules. It provides the
DNA sequence and if the DNA has an error, the molecules and proteins will have a
malfunction as well.
, genes are made from nucleotides being translated by a ribosome with tRNA to form an
amino acid chain(protein)
The DNA changes that are described in Henry's story are changes to the coding
strands of the CYP2C9 genes. What is the function of the coding strand and how
does it differ from the function of the template strand of Henry's CYP2C9 gene?
The coding strand of the DNA molecule (gene) represents the actual instruction for how
to assemble the enzyme during translation. The gene must first be transcribed and
converted into a piece of mRNA. RNA polymerase uses the template strand to build the
mRNA molecule by assembling mRNA nucleotides that are complementary to the DNA
nucleotides in the template strand. Since the coding strand of the DNA is also
complementary to the template strand, the mRNA that is constructed will be an exact
copy of the coding strand, with uracil (U) in place of thymine (T).
Consider the following DNA sequence found on a different portion of the coding
strand of Henry's CYP2C9 gene: TTACCGAGA
a. What would be the sequence of the template strand on this portion of the
gene?
b. How many triplet codes does this DNA sequence contain?
WITH VERIFIED SOLUTIONS GRADED A++
Why would someone with this type of mutation be at a much higher risk for
overdosing on a prescribed drug?
When a drug is prescribed, it is prescribed at a dose that assumes that the person's
body would be metabolizing (breaking down) the drug at a specific rate. If the person
lacks the enzymes (or enzyme functions) that are responsible for this metabolism, a
"normal" dose can become an "overdose" because the drug does not break down. In
addition, if the drug is prescribed as "multiple" or "daily" doses, the problem can become
amplified because new doses are being applied before the previous dose has been
removed from the body.
The underlying problem in this case resides in Henry's "genes." From what you
know about the function of a gene, explain how this problem led to a malfunction
in one of Henry's proteins (the CYP2C9 enzyme).
Gene is like a map for the cell to use when creating other molecules. It provides the
DNA sequence and if the DNA has an error, the molecules and proteins will have a
malfunction as well.
, genes are made from nucleotides being translated by a ribosome with tRNA to form an
amino acid chain(protein)
The DNA changes that are described in Henry's story are changes to the coding
strands of the CYP2C9 genes. What is the function of the coding strand and how
does it differ from the function of the template strand of Henry's CYP2C9 gene?
The coding strand of the DNA molecule (gene) represents the actual instruction for how
to assemble the enzyme during translation. The gene must first be transcribed and
converted into a piece of mRNA. RNA polymerase uses the template strand to build the
mRNA molecule by assembling mRNA nucleotides that are complementary to the DNA
nucleotides in the template strand. Since the coding strand of the DNA is also
complementary to the template strand, the mRNA that is constructed will be an exact
copy of the coding strand, with uracil (U) in place of thymine (T).
Consider the following DNA sequence found on a different portion of the coding
strand of Henry's CYP2C9 gene: TTACCGAGA
a. What would be the sequence of the template strand on this portion of the
gene?
b. How many triplet codes does this DNA sequence contain?
