Name: Score:
194 Multiple choice questions
Definition 1 of 194
Sexual activity, particularly MSM, undertaken while under the influence of drugs, particularly
drugs that "enhance" the sexual experience.
More common in patients on PREP/HAART, this is done to improve performance impaired by
disease or medication side effects.
NESARC SUD prevalence
What is Rimonabant?
Describe the function of the CB2 receptor and its locations.
Define "chemsex."
Term 2 of 194
What are the four factors that determine drug concentrations?
Ssri, especially with coexisting depression.
Nucleus accumbens, ventral tegmental area.
Humans cannot tell whether they have been given an active aas or placebo in studies, with
no demonstrated immediate reinforcing positive mood effects or euphoria.
any possible direct reward is small compared to other substances, such as cocaine, heroin,
alcohol, or nicotine, allowing noncompulsive aas use patterns (eg, once per week).
ADEM
absorption, distribution, elimination, metabolism
,Term 3 of 194
When body weights and alcohol consumption are equivalent, what is the relative blood alcohol
percentage in women versus men?
MDMA and other entactogens produce only minimal sensory effects (eg,
pseudohallucinations) but more prominent feelings of elation and connectedness.
It can also have more amphetamine-like stimulant effects mediated through the release or
reuptake inhibition of dopamine and noradrenaline.
ADEM
absorption, distribution, elimination, metabolism
Because women show less gastric metabolism of alcohol than men and have lower amounts
of ADH, when body weights are equivalent, women show a 20% to 25% higher blood
alcohol level than men following ingestion of the same amount of alcohol.
Medical workup includes a history and physical, and blood work (eg, free testosterone, sex
hormone-binding globulin, estradiol, LH, follicle-stimulating hormone, prolactin level,
prostate-specific antigen, lipids, comprehensive metabolic panel, and complete blood
count
,Definition 4 of 194
GHB binds to both GABA-B and GHB receptors (GHB is a naturally-occurring neurotransmitter).
GHB receptor binding regulates sleep/serotonin cycles and has an initial stimulant effect.
In larger doses GHB has more GABA-B agonism, leading to it's sedative properties in larger
doses.
As it is metabolized the GABA-B agonism wears off prior to GHB-receptor agonism, leading to
the characteristic sudden emergence from coma/sedation and rapid alertness.
Describe the serotonergic properties of high-dose dextromethorphan?
What is the role of finasteride and dutasteride during anabolic steroid use?
Is Caffeine Use Disorder included in the DSM-V?
What about Caffeine Intoxication?
Explain the mixed intoxication seen in GHB use.
What is the GHB "rebound effect"?
, Definition 5 of 194
Recommended: Methadone, fentanyl, hydromorphone (no toxic metabolites).
Caution: Hydrocodone (especially when formulated with acetaminophen). Morphine can be used
but should be avoided in co-existing renal failure.
Avoided: Meperidine, codeine
Tramadol should be avoided in patients with any seizure history and does carry a risk of serotonin
syndrome
**NSAIDs should be used cautiously or avoided in patients with cirrhosis as their bioavailability
may be significantly increased, putting patients at risk for kidney injury
How do the CNS effects of MDMA change with frequent use? How does this affect what we
know about its addictive potential?
What is the role of glutamate in the CNS?
What role does it play in the behaviors of addiction?
Which opioid receptors are targeted by methadone?
What other unique binding properties does it have?
What are the recommended opioid therapies in hepatic failure?
Which opioids should be avoided?
194 Multiple choice questions
Definition 1 of 194
Sexual activity, particularly MSM, undertaken while under the influence of drugs, particularly
drugs that "enhance" the sexual experience.
More common in patients on PREP/HAART, this is done to improve performance impaired by
disease or medication side effects.
NESARC SUD prevalence
What is Rimonabant?
Describe the function of the CB2 receptor and its locations.
Define "chemsex."
Term 2 of 194
What are the four factors that determine drug concentrations?
Ssri, especially with coexisting depression.
Nucleus accumbens, ventral tegmental area.
Humans cannot tell whether they have been given an active aas or placebo in studies, with
no demonstrated immediate reinforcing positive mood effects or euphoria.
any possible direct reward is small compared to other substances, such as cocaine, heroin,
alcohol, or nicotine, allowing noncompulsive aas use patterns (eg, once per week).
ADEM
absorption, distribution, elimination, metabolism
,Term 3 of 194
When body weights and alcohol consumption are equivalent, what is the relative blood alcohol
percentage in women versus men?
MDMA and other entactogens produce only minimal sensory effects (eg,
pseudohallucinations) but more prominent feelings of elation and connectedness.
It can also have more amphetamine-like stimulant effects mediated through the release or
reuptake inhibition of dopamine and noradrenaline.
ADEM
absorption, distribution, elimination, metabolism
Because women show less gastric metabolism of alcohol than men and have lower amounts
of ADH, when body weights are equivalent, women show a 20% to 25% higher blood
alcohol level than men following ingestion of the same amount of alcohol.
Medical workup includes a history and physical, and blood work (eg, free testosterone, sex
hormone-binding globulin, estradiol, LH, follicle-stimulating hormone, prolactin level,
prostate-specific antigen, lipids, comprehensive metabolic panel, and complete blood
count
,Definition 4 of 194
GHB binds to both GABA-B and GHB receptors (GHB is a naturally-occurring neurotransmitter).
GHB receptor binding regulates sleep/serotonin cycles and has an initial stimulant effect.
In larger doses GHB has more GABA-B agonism, leading to it's sedative properties in larger
doses.
As it is metabolized the GABA-B agonism wears off prior to GHB-receptor agonism, leading to
the characteristic sudden emergence from coma/sedation and rapid alertness.
Describe the serotonergic properties of high-dose dextromethorphan?
What is the role of finasteride and dutasteride during anabolic steroid use?
Is Caffeine Use Disorder included in the DSM-V?
What about Caffeine Intoxication?
Explain the mixed intoxication seen in GHB use.
What is the GHB "rebound effect"?
, Definition 5 of 194
Recommended: Methadone, fentanyl, hydromorphone (no toxic metabolites).
Caution: Hydrocodone (especially when formulated with acetaminophen). Morphine can be used
but should be avoided in co-existing renal failure.
Avoided: Meperidine, codeine
Tramadol should be avoided in patients with any seizure history and does carry a risk of serotonin
syndrome
**NSAIDs should be used cautiously or avoided in patients with cirrhosis as their bioavailability
may be significantly increased, putting patients at risk for kidney injury
How do the CNS effects of MDMA change with frequent use? How does this affect what we
know about its addictive potential?
What is the role of glutamate in the CNS?
What role does it play in the behaviors of addiction?
Which opioid receptors are targeted by methadone?
What other unique binding properties does it have?
What are the recommended opioid therapies in hepatic failure?
Which opioids should be avoided?
