NHL EXAM
What are the categories of follicular lymphoma? - Precise Answer ✔✔1)
classic FL
2) BCL2 rearrangement negative, CD23+ follicle center lymphoma/FL
with predominantly diffuse growth pattern
3) large cell lymphoma with IRF4/MUM1 expression (treat like
DLBCL)
4) pediatric type FL (in adults)
What does the FLIPI2 index take into account? - Precise Answer ✔✔-
age
- hgb level
- diameter of longest LN
- B2 microglobulin level
- BM involvement
What is the MoA of tazemetostat? - Precise Answer
✔✔methyltransferase inhibitor
- EZH2
What translocation predicts that a gastric MALT will have a poor
response to H pylori treatment? - Precise Answer ✔✔t(11;18)
, What virus is SMZL associated with? - Precise Answer ✔✔hep C - treat
the hep C and SMZL may regress
What are the less aggressive induction treatment regimens for mantle
cell? - Precise Answer ✔✔- rituximab + bendamustine
- VR-CAP
- R-CHOP
- lenalidomide + rituximab
- acalabrutinib + rituximab
maintenance therapy after less aggressive induction is rituximab q2
months for 2-3 years
What are the aggressive induction regimens for mantle cell? - Precise
Answer ✔✔- rituximab, dexamethasone, cytarabine + platinum x
4cycles followed by R-CHOP
- alternating R-CHOP + BTKi/RHA + platinum
- NORDIC regimen (dose intensified induction immunochemotherapy
with rituximab + cyclophosphamide, vincristine, doxorubicin,
prednisone alternating with rituximab + high dose cytarabine
- rituximab + bendamustine followed by rituximab/high dose cytarabine
- hyperCVAD + rituximab [not a preferred regimen]
When should one strongly consider giving CNS ppx to pts with
DLBCL? - Precise Answer ✔✔- high CNS IPI score
What are the categories of follicular lymphoma? - Precise Answer ✔✔1)
classic FL
2) BCL2 rearrangement negative, CD23+ follicle center lymphoma/FL
with predominantly diffuse growth pattern
3) large cell lymphoma with IRF4/MUM1 expression (treat like
DLBCL)
4) pediatric type FL (in adults)
What does the FLIPI2 index take into account? - Precise Answer ✔✔-
age
- hgb level
- diameter of longest LN
- B2 microglobulin level
- BM involvement
What is the MoA of tazemetostat? - Precise Answer
✔✔methyltransferase inhibitor
- EZH2
What translocation predicts that a gastric MALT will have a poor
response to H pylori treatment? - Precise Answer ✔✔t(11;18)
, What virus is SMZL associated with? - Precise Answer ✔✔hep C - treat
the hep C and SMZL may regress
What are the less aggressive induction treatment regimens for mantle
cell? - Precise Answer ✔✔- rituximab + bendamustine
- VR-CAP
- R-CHOP
- lenalidomide + rituximab
- acalabrutinib + rituximab
maintenance therapy after less aggressive induction is rituximab q2
months for 2-3 years
What are the aggressive induction regimens for mantle cell? - Precise
Answer ✔✔- rituximab, dexamethasone, cytarabine + platinum x
4cycles followed by R-CHOP
- alternating R-CHOP + BTKi/RHA + platinum
- NORDIC regimen (dose intensified induction immunochemotherapy
with rituximab + cyclophosphamide, vincristine, doxorubicin,
prednisone alternating with rituximab + high dose cytarabine
- rituximab + bendamustine followed by rituximab/high dose cytarabine
- hyperCVAD + rituximab [not a preferred regimen]
When should one strongly consider giving CNS ppx to pts with
DLBCL? - Precise Answer ✔✔- high CNS IPI score
