PT3 - COMPLICATIONS OF CANCER
what is the most common dose-limiting SE of cytotoxic agents?
- Answer Myelosuppression
other than chemotherapy, what other agents can cause
myelosuppression? - Answer small molecular tyrosine kinase
inhibitors/targeted agents: BCR-ABL, EGFR, VEGF, FLT3,
ALK, HER2
what regions of the body increases risk of myelosuppression w
concurrent radiation? - Answer chest and pelvic region
Myelosuppression includes... - Answer Anemia, Neutropenia,
and Thrombocytopenia
Anemia incidence depends on what? - Answer Type and
duration of therapy &
Type and stage of underlying malignancy
what is the most common sign of anemia? - Answer fatigue
, what are the tx options available for anemia? - Answer RBC
transfusion & Erythropoiesis-stimulating agents (Epoetin alfa &
Darbepoetin alfa)
what is the target hemoglobin for anemia tx? - Answer 10-12g/dl
- risk of cardiovascular events with higher values and rate of rise
Epoetin & Darbepoetin box warning - Answer Increased risk for
mortality and nonfatal myocardial infxn, stroke, heart failure and
thrombosis
what agents are used in the tx for neutropenia? - Answer
Filgrastrim, Sargramostim, Pegfilgrastim
what are the SEs of Filgrastrim and Pegfilgrastim? - Answer
Bone pain, HSR, allergic rxns
Pegfilgrastrim is dosed _____ and Filgrastrim is dosed _______
- Answer once daily; multiple times daily
which of the neutropenia txs can cause pleural and pericardial
effusions, capillary leak syndrome, thrombus formation at
higher doses? - Answer Sargramostim
what is the most common dose-limiting SE of cytotoxic agents?
- Answer Myelosuppression
other than chemotherapy, what other agents can cause
myelosuppression? - Answer small molecular tyrosine kinase
inhibitors/targeted agents: BCR-ABL, EGFR, VEGF, FLT3,
ALK, HER2
what regions of the body increases risk of myelosuppression w
concurrent radiation? - Answer chest and pelvic region
Myelosuppression includes... - Answer Anemia, Neutropenia,
and Thrombocytopenia
Anemia incidence depends on what? - Answer Type and
duration of therapy &
Type and stage of underlying malignancy
what is the most common sign of anemia? - Answer fatigue
, what are the tx options available for anemia? - Answer RBC
transfusion & Erythropoiesis-stimulating agents (Epoetin alfa &
Darbepoetin alfa)
what is the target hemoglobin for anemia tx? - Answer 10-12g/dl
- risk of cardiovascular events with higher values and rate of rise
Epoetin & Darbepoetin box warning - Answer Increased risk for
mortality and nonfatal myocardial infxn, stroke, heart failure and
thrombosis
what agents are used in the tx for neutropenia? - Answer
Filgrastrim, Sargramostim, Pegfilgrastim
what are the SEs of Filgrastrim and Pegfilgrastim? - Answer
Bone pain, HSR, allergic rxns
Pegfilgrastrim is dosed _____ and Filgrastrim is dosed _______
- Answer once daily; multiple times daily
which of the neutropenia txs can cause pleural and pericardial
effusions, capillary leak syndrome, thrombus formation at
higher doses? - Answer Sargramostim
