Test Bank For Pharmacotherapeutics For Advanced
Practice; A Practical Approach 5th Edition Arcangelo
Test Bank
Chapter 1 Issues for the Professional in Drug Therapy
MULTIPLE CHOICE
1. Nurse professional prescriptive authority is regulated by:
A. The National Council of State Boards of Nursing
B. The U.S. Drug Enforcement Administration
C. The State Board of Nursing for each state
D. The State Board of Pharmacy
ANSWER: C PTS: 1
2. Physician Assistant (PA) prescriptive authority is regulated by:
A. The National Council of State Boards of Nursing
B. The U.S. Drug Enforcement Administration
C. The State Board of Nursing
D. The State Board of Medical Examiners
ANSWER: D PTS: 1
3. Clinical judgment in prescribing includes:
A. Factoring in the cost to the patient of the medication prescribed
B. Always prescribing the newest medication available for the disease process
C. Handing out drug samples to poor patients
D. Prescribing all generic medications to cut costs
ANSWER: A PTS: 1
4. Criteria for choosing an effective drug for a disorder include:
A. Asking the patient what drug they think would work best for them
B. Consulting nationally recognized guidelines for disease management
C. Prescribing medications that are available as samples before writing a prescription
D. Following U.S. Drug Enforcement Administration (DEA) guidelines
for prescribing
ANSWER: B PTS: 1
5. Nurse professional practice may thrive under health-care reform due to:
A. The demonstrated ability of nurse professionals to control costs and improve
patient outcomes
B. The fact that nurse professionals will be able to practice independently
C. The fact that nurse professionals will have full reimbursement under
health-care reform
D. The ability to shift accountability for Medicaid to the state level
ANSWER: A PTS: 1
,Chapter 2.Pharmacokinetic Basis of Therapeutics and Pharmacodynamic
MULTIPLE CHOICE
1. A patient’s nutritional intake and lab work reflects hypoalbuminemia. This is
critical to prescribing because:
A. Distribution of Medicinesto target tissue may be affected
B. The solubility of the drug will not match the site of absorption
C. There will be less free drug available to generate an effect
D. Medicinesbound to albumin are readily excreted by the kidney
ANSWER: A PTS: 1
2. Medicines that have a significant first-pass effect:
A. Must be given by the enteral (oral) route only
B. Bypass the hepatic circulation
C. Are rapidly metabolized by the liver and may have little if any desired action
D. Are converted by the liver to more active and fat-soluble forms
ANSWER: C PTS: 1
3. The route of excretion of a volatile drug will likely be:
A. The kidneys
B. The lungs
C. The bile and feces
D. The skin
ANSWER: B PTS: 1
4. Medroxyprogesterone (Depo Provera) is prescribed IM to create a storage reservoir
of the drug. Storage reservoirs:
A. Assure that the drug will reach its intended target tissue
B. Are the reason for giving loading doses
C. Increase the length of time a drug is available and active
D. Are most common in collagen tissues
ANSWER: C PTS: 1
5. The NP chooses to give cephalexin every 8 hours based on knowledge of the drug’s:
A. Propensity to go to the target receptor
B. Biological half-life
C. Pharmacodynamics
D. Safety and side effects
ANSWER: B PTS: 1
6. Azithromycin dosing requires the first day’s dose be twice those of the other 4 days
of the prescription. This is considered a loading dose. A loading dose:
A. Rapidly achieves drug levels in the therapeutic range
B. Requires four to five half-lives to attain
,C. Is influenced by renal function
, D. Is directly related to the drug circulating to the target tissues
ANSWER: A PTS: 1
7. The point in time on the drug concentration curve that indicates the first sign of a
therapeutic effect is the:
A. Minimum adverse effect level
B. Peak of action
C. Onset of action
D. Therapeutic range
ANSWER: C PTS: 1
8. Phenytoin requires a trough level be drawn. Peak and trough levels are done:
A. When the drug has a wide therapeutic range
B. When the drug will be administered for a short time only
C. When there is a high correlation between the dose and saturation of receptor sites
D. To determine if a drug is in the therapeutic range
ANSWER: D PTS: 1
9. A laboratory result indicates the peak level for a drug is above the minimum
toxic concentration. This meANSWER that the:
A. Concentration will produce therapeutic effects
B. Concentration will produce an adverse response
C. Time between doses must be shortened
D. Duration of action of the drug is too long
ANSWER: B PTS: 1
10. Medicinesthat are receptor agonists may demonstrate what property?
A. Irreversible binding to the drug receptor site
B. Up-regulation with chronic use
C. Desensitization or down-regulation with continuous use
D. Inverse relationship between drug concentration and drug action
ANSWER: C PTS: 1
11. Medicinesthat are receptor antagonists, such as beta blockers, may cause:
A. Down-regulation of the drug receptor
B. An exaggerated response if abruptly discontinued
C. Partial blockade of the effects of agonist drugs
D. An exaggerated response to competitive drug agonists
ANSWER: B PTS: 1
12. Factors that affect gastric drug absorption include:
A. Liver enzyme activity
B. Protein-binding properties of the drug molecule
C. Lipid solubility of the drug
D. Ability to chew and swallow
Practice; A Practical Approach 5th Edition Arcangelo
Test Bank
Chapter 1 Issues for the Professional in Drug Therapy
MULTIPLE CHOICE
1. Nurse professional prescriptive authority is regulated by:
A. The National Council of State Boards of Nursing
B. The U.S. Drug Enforcement Administration
C. The State Board of Nursing for each state
D. The State Board of Pharmacy
ANSWER: C PTS: 1
2. Physician Assistant (PA) prescriptive authority is regulated by:
A. The National Council of State Boards of Nursing
B. The U.S. Drug Enforcement Administration
C. The State Board of Nursing
D. The State Board of Medical Examiners
ANSWER: D PTS: 1
3. Clinical judgment in prescribing includes:
A. Factoring in the cost to the patient of the medication prescribed
B. Always prescribing the newest medication available for the disease process
C. Handing out drug samples to poor patients
D. Prescribing all generic medications to cut costs
ANSWER: A PTS: 1
4. Criteria for choosing an effective drug for a disorder include:
A. Asking the patient what drug they think would work best for them
B. Consulting nationally recognized guidelines for disease management
C. Prescribing medications that are available as samples before writing a prescription
D. Following U.S. Drug Enforcement Administration (DEA) guidelines
for prescribing
ANSWER: B PTS: 1
5. Nurse professional practice may thrive under health-care reform due to:
A. The demonstrated ability of nurse professionals to control costs and improve
patient outcomes
B. The fact that nurse professionals will be able to practice independently
C. The fact that nurse professionals will have full reimbursement under
health-care reform
D. The ability to shift accountability for Medicaid to the state level
ANSWER: A PTS: 1
,Chapter 2.Pharmacokinetic Basis of Therapeutics and Pharmacodynamic
MULTIPLE CHOICE
1. A patient’s nutritional intake and lab work reflects hypoalbuminemia. This is
critical to prescribing because:
A. Distribution of Medicinesto target tissue may be affected
B. The solubility of the drug will not match the site of absorption
C. There will be less free drug available to generate an effect
D. Medicinesbound to albumin are readily excreted by the kidney
ANSWER: A PTS: 1
2. Medicines that have a significant first-pass effect:
A. Must be given by the enteral (oral) route only
B. Bypass the hepatic circulation
C. Are rapidly metabolized by the liver and may have little if any desired action
D. Are converted by the liver to more active and fat-soluble forms
ANSWER: C PTS: 1
3. The route of excretion of a volatile drug will likely be:
A. The kidneys
B. The lungs
C. The bile and feces
D. The skin
ANSWER: B PTS: 1
4. Medroxyprogesterone (Depo Provera) is prescribed IM to create a storage reservoir
of the drug. Storage reservoirs:
A. Assure that the drug will reach its intended target tissue
B. Are the reason for giving loading doses
C. Increase the length of time a drug is available and active
D. Are most common in collagen tissues
ANSWER: C PTS: 1
5. The NP chooses to give cephalexin every 8 hours based on knowledge of the drug’s:
A. Propensity to go to the target receptor
B. Biological half-life
C. Pharmacodynamics
D. Safety and side effects
ANSWER: B PTS: 1
6. Azithromycin dosing requires the first day’s dose be twice those of the other 4 days
of the prescription. This is considered a loading dose. A loading dose:
A. Rapidly achieves drug levels in the therapeutic range
B. Requires four to five half-lives to attain
,C. Is influenced by renal function
, D. Is directly related to the drug circulating to the target tissues
ANSWER: A PTS: 1
7. The point in time on the drug concentration curve that indicates the first sign of a
therapeutic effect is the:
A. Minimum adverse effect level
B. Peak of action
C. Onset of action
D. Therapeutic range
ANSWER: C PTS: 1
8. Phenytoin requires a trough level be drawn. Peak and trough levels are done:
A. When the drug has a wide therapeutic range
B. When the drug will be administered for a short time only
C. When there is a high correlation between the dose and saturation of receptor sites
D. To determine if a drug is in the therapeutic range
ANSWER: D PTS: 1
9. A laboratory result indicates the peak level for a drug is above the minimum
toxic concentration. This meANSWER that the:
A. Concentration will produce therapeutic effects
B. Concentration will produce an adverse response
C. Time between doses must be shortened
D. Duration of action of the drug is too long
ANSWER: B PTS: 1
10. Medicinesthat are receptor agonists may demonstrate what property?
A. Irreversible binding to the drug receptor site
B. Up-regulation with chronic use
C. Desensitization or down-regulation with continuous use
D. Inverse relationship between drug concentration and drug action
ANSWER: C PTS: 1
11. Medicinesthat are receptor antagonists, such as beta blockers, may cause:
A. Down-regulation of the drug receptor
B. An exaggerated response if abruptly discontinued
C. Partial blockade of the effects of agonist drugs
D. An exaggerated response to competitive drug agonists
ANSWER: B PTS: 1
12. Factors that affect gastric drug absorption include:
A. Liver enzyme activity
B. Protein-binding properties of the drug molecule
C. Lipid solubility of the drug
D. Ability to chew and swallow
