HEMATOLOGY AND ONCOLOGY PANCE/PANRE EXAM
QUESTIONS AND VERIFIED ANSWERS GRADED A++
Auer rods on peripheral smear indicate...?
acute myeloblastic leukemia (AML)
60 year old male with severe anemia, decreased neutrophil count, and small,
abnormal B lymphocytes in the bone marrow (>30%) with levels at 90,000 per
cubic millimeter. Has painless cervical lymphadenopathy and
hepatosplenomegaly. Likely diagnosis?
Chronic lymphocytic leukemia (CLL)
Bone marrow aspiration and biopsy reveals the presence of the Philadelphia (Ph)
chromosome in dividing marrow cells. Likely diagnosis?
Chromic myeloblastic leukemia (CML)
Follicular, cleaved cell, lymphocytic, histolytic
Hodgkins Lymphoma
Reed Sternberg cell
Hodgkin's lymphoma
Plasma cells, monoclonal protein
Multiple myeloma
What disease is characterized by abnormal monoclonal protein, anemia, and lytic
bone lesions?
Multiple myeloma
, 30 year old white male with 3 month history of painless enlargement of bilateral
cervical lymph nodes, fever, and night sweats. Likely diagnosis?
Hodgkin's disease
What hematologic measurement is abnormal in chronic heavy alcohol use?
Mean corpuscular volume
Most frequent cause of B12 deficiency in patients with classic pernicious anemia
Lack of intrinsic factor
In thalassemia anemia, what causes the anemia?
Shortened lifespan of RBCs
Teenage African American female presents with severe bone and joint pain. CBC
shows severe anemia and elevate leukocyte and platelet counts. Most likely
diagnosis?
Sickle cell disease
What 2 tests are used to confirm the diagnosis of homozygous sickle cell
disease?
Peripheral smear and hemoglobin electrophoresis
The most helpful test to distinguish megaloblastic from nonmegaloblastic
macrocytic anemia
Peripheral smear
What is the most common initial presentation of sickle cell disease?
Failure to thrive in a child at risk
QUESTIONS AND VERIFIED ANSWERS GRADED A++
Auer rods on peripheral smear indicate...?
acute myeloblastic leukemia (AML)
60 year old male with severe anemia, decreased neutrophil count, and small,
abnormal B lymphocytes in the bone marrow (>30%) with levels at 90,000 per
cubic millimeter. Has painless cervical lymphadenopathy and
hepatosplenomegaly. Likely diagnosis?
Chronic lymphocytic leukemia (CLL)
Bone marrow aspiration and biopsy reveals the presence of the Philadelphia (Ph)
chromosome in dividing marrow cells. Likely diagnosis?
Chromic myeloblastic leukemia (CML)
Follicular, cleaved cell, lymphocytic, histolytic
Hodgkins Lymphoma
Reed Sternberg cell
Hodgkin's lymphoma
Plasma cells, monoclonal protein
Multiple myeloma
What disease is characterized by abnormal monoclonal protein, anemia, and lytic
bone lesions?
Multiple myeloma
, 30 year old white male with 3 month history of painless enlargement of bilateral
cervical lymph nodes, fever, and night sweats. Likely diagnosis?
Hodgkin's disease
What hematologic measurement is abnormal in chronic heavy alcohol use?
Mean corpuscular volume
Most frequent cause of B12 deficiency in patients with classic pernicious anemia
Lack of intrinsic factor
In thalassemia anemia, what causes the anemia?
Shortened lifespan of RBCs
Teenage African American female presents with severe bone and joint pain. CBC
shows severe anemia and elevate leukocyte and platelet counts. Most likely
diagnosis?
Sickle cell disease
What 2 tests are used to confirm the diagnosis of homozygous sickle cell
disease?
Peripheral smear and hemoglobin electrophoresis
The most helpful test to distinguish megaloblastic from nonmegaloblastic
macrocytic anemia
Peripheral smear
What is the most common initial presentation of sickle cell disease?
Failure to thrive in a child at risk
