Nur 619 Pharm Exam 1
2024
, Pharmacogenomics - the study of genetically determined variations in the response to
drugs
Pharmacokinetics - The way the body processes drugs. Involves 4 processes of:
-absorption
-distribution
-metabolism
-excretion
Drug clearance - The process of metabolism and excretion/
The disappearance of the drug from the patient's serum
Absorption - The process by which drug molecules move from their site of
administration, across one or more cell membranes, in order to gain entry to the blood
Driving force of absorption - Concentration gradient = Concentration on either side of
the membrane
Concentration Gradient - Passive diffusion- from high concentration to low
concentration. Does NOT require energy
Routes of drug administration that do NOT involve the absorption process - -IV
-Intraarterial
Absorption: Fastest to slowest drug formulations - FASTEST
-liquids
-suspensions
-powders
-capsules
-tablets
-enteric coated tablets
-sustained release tablets
SLOWEST
Factors that determine the rate and extent of drug absorption - -solubility (or
dissolvability) of the drug
-physical properties of the drug
-area of absorptive surface
-blood supply at absorptive surface
-length of time of contact with absorptive surface
Cell membranes are composed of lipids. --> Fat-soluble molecules cross the membrane
easier than water-soluble. What are fat soluble molecules called? - Non-ionized
Non-polarized
***Acidic
2024
, Pharmacogenomics - the study of genetically determined variations in the response to
drugs
Pharmacokinetics - The way the body processes drugs. Involves 4 processes of:
-absorption
-distribution
-metabolism
-excretion
Drug clearance - The process of metabolism and excretion/
The disappearance of the drug from the patient's serum
Absorption - The process by which drug molecules move from their site of
administration, across one or more cell membranes, in order to gain entry to the blood
Driving force of absorption - Concentration gradient = Concentration on either side of
the membrane
Concentration Gradient - Passive diffusion- from high concentration to low
concentration. Does NOT require energy
Routes of drug administration that do NOT involve the absorption process - -IV
-Intraarterial
Absorption: Fastest to slowest drug formulations - FASTEST
-liquids
-suspensions
-powders
-capsules
-tablets
-enteric coated tablets
-sustained release tablets
SLOWEST
Factors that determine the rate and extent of drug absorption - -solubility (or
dissolvability) of the drug
-physical properties of the drug
-area of absorptive surface
-blood supply at absorptive surface
-length of time of contact with absorptive surface
Cell membranes are composed of lipids. --> Fat-soluble molecules cross the membrane
easier than water-soluble. What are fat soluble molecules called? - Non-ionized
Non-polarized
***Acidic
