MBPA 3412:
ONCOPATHOLOGY
Dr. A. Irungu
,Scope
• Recap – previous classes
• Hallmarks of Cancer
• Self-sufficiency in Growth Signals
• Insensitivity to growth inhibitory signals
• RB gene: Governor of the Cell Cycle
• TP53 gene: Guardian of the genome
• Transforming growth factor-B pathway
• Contact inhibition, NF2 and APC
• Evasion of cell death
• Autophagy
• Limitless replicative potential
• Development of sustained angiogenesis
, Insensitivity to Growth Inhibitory Signals
• Failure of growth inhibition is fundamental in carcinogenesis
• The proteins that apply brakes to cell proliferation are called tumou
suppressor genes
• Disruptions of such genes renders cells refractory to growth inhibit
and mimics the growth-promoting effects of oncogenes
• Unlike oncogenes both copies tumour suppressor gene must be
dysfunctional for tumour development to occur
ONCOPATHOLOGY
Dr. A. Irungu
,Scope
• Recap – previous classes
• Hallmarks of Cancer
• Self-sufficiency in Growth Signals
• Insensitivity to growth inhibitory signals
• RB gene: Governor of the Cell Cycle
• TP53 gene: Guardian of the genome
• Transforming growth factor-B pathway
• Contact inhibition, NF2 and APC
• Evasion of cell death
• Autophagy
• Limitless replicative potential
• Development of sustained angiogenesis
, Insensitivity to Growth Inhibitory Signals
• Failure of growth inhibition is fundamental in carcinogenesis
• The proteins that apply brakes to cell proliferation are called tumou
suppressor genes
• Disruptions of such genes renders cells refractory to growth inhibit
and mimics the growth-promoting effects of oncogenes
• Unlike oncogenes both copies tumour suppressor gene must be
dysfunctional for tumour development to occur
