COMPLETE SOLUTIONS VERIFIED
Inflammation
Coordinated vascular and cellular response of the body to injury and trauma
-Has both protective (immune) & curative features
Central themes of inflammation
-Vascular response (blood vessels)
-Humoral response (blood)
-Neurologic response (nerve)
-Cellular response (cells)
vascular response
Increased porosity or leakiness of blood vessels
humoral response
(blood)
movement of fluid out of the vasculature and into the interstitial spaces
neurologic response
(nerve)
pain
cellular response
, (cells)
-recruitment of platelets
-influx of neutrophils, monocytes and macrophages
cardinal signs of inflammation
-erythema: vasodilation and increased blood flow
-heat: vasodilation and increased blood flow
-edema: fluid and cells leaking from local blood vessels into extravascular spaces -->
swelling
-pain: direct trauma; mediation by bradykinins, histamines, serotonin; internal pressure
secondary to edema
-loss of function
pro-inflammatory state
facilitate the inflammatory response for the cardinal signs and symptoms of
inflammation
examples of pro-inflammatories
-TNF-alpha
-Interlukin-1 & 6, histamines, VEGF, etc.
sequence of tissue repair
-Hemostasis (0-24 hours)/inflammation(1-6 days)
-proliferation (4-24 days)
-remodeling (21 days- 2+ years)
Hemostasis/Inflammation