PHYSIOLOGY: BRS CHAPTER 2 EXAM QUESTIONS AND
ANSWERS WITH COMPLETE SOLUTIONS VERIFIED
What neurotransmitter is secreted at the postganglionic synapse in sympathetic
innervation to the sweat glands?
Ach (NOT NE!)
What neurotransmitter is secreted at the ganglion in parasympathetic neurons?
Ach
What receptor exists at the ganglion in ALL autonomic neurons?
Nicotinic
What receptor exists on skeletal muscle at the NMJ?
Nicotinic
What neurotransmitter is secreted onto adrenal cells to promote release of NE/E?
Ach
What receptor exists at the effector organ in parasympathetic neurons?
Muscarinic
M1: CNS
M2: Heart
M3: Glands, smooth muscle
What is the molecular effect of norepinephrine binding to an alpha-1 receptor?
, Increased IP3/Calcium (Gq)
(Makes sense - calcium is causing vasoconstriction through contraction of vascular
smooth muscle).
What is the molecular effect of norepinephrine binding to an alpha-2 receptor?
Decreased cAMP (Gi)
What is the molecular effect of norepinephrine binding to a beta-1 receptor?
Increased cAMP (Gs)
What is the molecular effect of epinephrine binding to a beta-2 receptor?
Increased cAMP (Gs)
What is the molecular effect of Ach binding to a nicotinic receptor?
Opening of sodium and potassium channels (ligand gated ion channel)
What is the molecular effect of Ach binding to an M1 receptor?
Increased IP3/Ca (Gq)
What is the molecular effect of Ach binding to an M2 receptor?
Decreased cAMP (Gi)
What is the molecular effect of Ach binding to an M3 receptor?
Increased IP3/Ca (Gq)
What are the physiologic effects (4) of beta-1 receptor activation?
Increased HR, contractility, and AV nodal conduction.
Increased renin secretion
ANSWERS WITH COMPLETE SOLUTIONS VERIFIED
What neurotransmitter is secreted at the postganglionic synapse in sympathetic
innervation to the sweat glands?
Ach (NOT NE!)
What neurotransmitter is secreted at the ganglion in parasympathetic neurons?
Ach
What receptor exists at the ganglion in ALL autonomic neurons?
Nicotinic
What receptor exists on skeletal muscle at the NMJ?
Nicotinic
What neurotransmitter is secreted onto adrenal cells to promote release of NE/E?
Ach
What receptor exists at the effector organ in parasympathetic neurons?
Muscarinic
M1: CNS
M2: Heart
M3: Glands, smooth muscle
What is the molecular effect of norepinephrine binding to an alpha-1 receptor?
, Increased IP3/Calcium (Gq)
(Makes sense - calcium is causing vasoconstriction through contraction of vascular
smooth muscle).
What is the molecular effect of norepinephrine binding to an alpha-2 receptor?
Decreased cAMP (Gi)
What is the molecular effect of norepinephrine binding to a beta-1 receptor?
Increased cAMP (Gs)
What is the molecular effect of epinephrine binding to a beta-2 receptor?
Increased cAMP (Gs)
What is the molecular effect of Ach binding to a nicotinic receptor?
Opening of sodium and potassium channels (ligand gated ion channel)
What is the molecular effect of Ach binding to an M1 receptor?
Increased IP3/Ca (Gq)
What is the molecular effect of Ach binding to an M2 receptor?
Decreased cAMP (Gi)
What is the molecular effect of Ach binding to an M3 receptor?
Increased IP3/Ca (Gq)
What are the physiologic effects (4) of beta-1 receptor activation?
Increased HR, contractility, and AV nodal conduction.
Increased renin secretion
