Inappropriate Antidiuertic
Hormone (SIADH) with 100%
correct answers (latest
update)
What is SIADH - answer -results from abnormally HIGH production or
sustained secretion of ADH
-characterized by water overload and resultant hyponatremia due to
hemodilution
Action of ADH - answer to reabsorb water in the kidneys
Causes of SIADH - answer vary & include CNS disorders:
-tumors in the brain or neck
-side effects of medications such as NSAIDs, psychotropic
medication, & bronchogenic carcinoma
Where does SIADH most commonly occur? - answer SMALL CELL
LUNG CANCER
Labs that need to be evaluated for normal renal function - answer -
BUN
- creatinine
- GFR (normal >60)
Characteristics of SIADH - answer -fluid retention
, -serum hypoosmolality
-dilutional hyponatremia
-hypochloremia
-concentrated urine in the presence of normal or increased
intravascular volume & normal renal function
Diagnostics - answer -urine and serum osmolality
-dilutional hyponatremia
a.) Na <134 mEq/L (normal 135-145)
*as sodium levels drop, LOC will start diminishing*
b.) Osmolality <280
c.) Specific gravity >1.025
SIADH patient labs will present as what? - answer low sodium
low osmolality
high specific gravity
Clinical manifestations - answer -low urine output (barely meeting
<30 mL)
-increased body weight
-muscle cramping
-pain
-weakness
-thirst
-DOE (dyspnea on exertion)
-fatigue
What is patient at risk for with LOW sodium levels? - answer
Seizures causing increase in ICP