BPS338 SIHD Drugs and Mechanisms (CleExam1) with 100- correct answers

BPS338 SIHD: Drugs and
Mechanisms (CleExam1) with
100% correct answers
Equation for cardiac output
CO = HR x SV
SV is determined by ______________, __________________, and
________________
Preload, afterload, contractility
Pressure that fills the ventricl is referred to as...
-Increases result in increase to SV and co
-Increases EDP and EDV
Preload
Concept that refers to the more force being produced the more the
ventricle wall is stretched
-Intrinsic properties of the cardiac sarcomeres (stretch, tension) and
Ca++ release machinery
Frank-Starling Mechanism




The pressure and/or resistance that the heart has to actively work
against
-Increases result in decreases to SV and CO
Afterload

, Force generated for a given sarcomere/fiber length
-can be modified by catechlamines, Symp/Parasymp activity,
Inotropes, Preload, Afterload (anrep effect), and HR (Bowditch
Effect)
Contractility (inotropy)




Organ with the highest oxygen demand in the body?
Heart

Note: Coronary A-VO2 difference is the highest of any circulation
Does the majority of flow through the heart take place during
systole or diastole?
Diastole




Equation for Blood Flow (Q)?
Blood flow = Change in pressure / resistance

or
Q= deltaP / R
Small changes in __________ can have large effects on flow / pressure
Radius

Note: vasodilation and constriction can cause large changes in
radius