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Pathophysiology

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Lecture notes of 64 pages for the course Pathophysiology at Lebanese International University (Many chapters)

Institution
Course

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, THE NATURE OfDISEASE
o One




diseases that arises and lasts short time.
Acute disease : a
rapidly a

Crinic disease : a disease that arises
slowly and lasts a
long period of time
pathology : the
study of changes in
body structure and
function ,
the result of the disease.

the
etiology : cause
of disease.


pathogenesis : the process by which the disease develops .




idiopathic : a disease that has a known
origin Jetilogy)
iatrogenic that (e :
: a disease is caused
by a
byproduct medical or
physician fault)
Anatomic
pathology : a disease that courses structural modifications
examination
gross :
by an unaided
eye Ce : autopsy biopsy)
,


microscopic examination : done
by a microscope .


the
clinical
pathology :
study of a disease
by laboratory tests
.

, ·y CULARRESPONSE
AND AGING
URY,



All alls are wissible


A
trophy
decrease in all size
.
· reduction in the number
of organelles = reduction in
Oxygen consumption
Insulin/IGF-I ↓L
3 apoptosis
proteolyssynthetic
·




processes
-presence of catabolic signs
·
S causes
of atrophy : - disuse (not using it) (ex : extremities that have been encased in casts) .
denervation (loss of nerves) (ex : limbs).
· .




paralyzed
·
loss
of endocine stimulation .
(ex : menopause, los of restrogen)
·
inadequate nutition

· ischemia/ decreased blood flow (thus , no
oxygen is arrived to the -
clls)




Hypertrophy
cell
increase in
size
· it can be either
physiologic or
pathologic .




& N

- -




adaptive compensatory
thickening of winary thecaroftheremoval
the
CeX :
bladder myocardial
Lex in one
,

hypertrophy in order to compensate) .

, Hyperplasia
increase in the number of .
cells

·
hyperplasia can not occur in neurons/nerve alls.

· it can be
physiologic or
non-physiologic pathologic ,
simulation
(eX : excessive hormonal : excess olstrogen = endometrial
hypepl.
=> abnormal menstrual bleeding/excess androgens =
Benign prostatic hypepl .
N
excess
growth factors => Skin wants due to papillomavines

(IX : breast and uteves
hormonal
compensatory
enlargement
due to os
a
-




Lexi sector ,the
regeneratio
liver after




· it's important in wound
healing as wel

·
hypertrophy and hyperplasia can occur at the same time in the case
of uters enlargement
-
.
stimulation
during pregnancy after an
restrogen


Metaplasia
in cell
change type
· results from undifferenciated stem alls

the smoker when there's
·
examples : in case
of a
heavy , or a
reflux
ciliated epithelial alls
(more protective but
are
transformed to
stratifiedsquamoa
can live shorter survive
more)

Dysplasia

dranged all growth
·

pap
test is done to prevent pap smear (cancer ofthe verine cervix)

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Uploaded on
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Number of pages
64
Written in
2024/2025
Type
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Contains
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