BLANKENSHIP FINAL EXAM LATEST WCU ACCURATE
FALL-SPRING TERM GRADED A+
Give examples of meal time insulin? - ANSWER: Aspart, Lispro, Regular
Give examples of Basal insulin and how they are typically taken? - ANSWER: NPH
(BID) and Glargine (daily) (Again, envelope person, please tell your group to know
what these drugs look like on the charts)
Which type of insulin has no peak? - ANSWER: Glargine
What is added to rapid acting insulin that extend its half life? - ANSWER: Protamine
What is the MOA of insulin? - ANSWER: The Tyrosine Kinase Insulin receptor is
activated by insulin binding to the extracellular subunits. This signal translates into
the tyrosine kinase domains. These domains cause a series of phosphorylation
reactions to cause the translocation of GLUT for the transportation of glucose into
the cell.
To diagnose type 2 diabetes, what is the fasting glucose and HgB A1C? - ANSWER:
>126 and >6.5: normal is < 100 and <5.5
What is the difference between type 1 and type 2 diabetes? - ANSWER: Age, weight,
insulin dependence, one is autoimmune, genetics, ketoacidosis prevalence
What is the rare but dangerous side effect caused by the first-line diabetic oral
medication which works in the liver? - ANSWER: (Metformin) Lactic Acidosis
What is the #1 SE of Metformin? - ANSWER: GI and diarrhea (should resolve over
time, but some patients do not want to wait for that resolution and stop taking it)
Name one circumstance that one should avoid using Metformin? - ANSWER: Elderly
especially with renal insufficiency, excessive alcohol hepatic failure, excessive alcohol
intake, radiological study with contrast
What is a diabetic oral med that has the MOA of binding to PPAR gamma in adipose
tissue (increased insulin receptor numbers available)? - ANSWER: Pioglitazone
What is a SE of Pioglitazone and what is its MOA? - ANSWER: Edema (do not use in
patients with systematic HF)
What is the special alert with Pioglitazone? - ANSWER: Bladder CA, cause or
exacerbate CHF (edema), and increased risk of macula edema
What is the MOA of Acarbose? - ANSWER: alpha glucosidase inhibitor (prevents
postprandial rise of blood glucose)
FALL-SPRING TERM GRADED A+
Give examples of meal time insulin? - ANSWER: Aspart, Lispro, Regular
Give examples of Basal insulin and how they are typically taken? - ANSWER: NPH
(BID) and Glargine (daily) (Again, envelope person, please tell your group to know
what these drugs look like on the charts)
Which type of insulin has no peak? - ANSWER: Glargine
What is added to rapid acting insulin that extend its half life? - ANSWER: Protamine
What is the MOA of insulin? - ANSWER: The Tyrosine Kinase Insulin receptor is
activated by insulin binding to the extracellular subunits. This signal translates into
the tyrosine kinase domains. These domains cause a series of phosphorylation
reactions to cause the translocation of GLUT for the transportation of glucose into
the cell.
To diagnose type 2 diabetes, what is the fasting glucose and HgB A1C? - ANSWER:
>126 and >6.5: normal is < 100 and <5.5
What is the difference between type 1 and type 2 diabetes? - ANSWER: Age, weight,
insulin dependence, one is autoimmune, genetics, ketoacidosis prevalence
What is the rare but dangerous side effect caused by the first-line diabetic oral
medication which works in the liver? - ANSWER: (Metformin) Lactic Acidosis
What is the #1 SE of Metformin? - ANSWER: GI and diarrhea (should resolve over
time, but some patients do not want to wait for that resolution and stop taking it)
Name one circumstance that one should avoid using Metformin? - ANSWER: Elderly
especially with renal insufficiency, excessive alcohol hepatic failure, excessive alcohol
intake, radiological study with contrast
What is a diabetic oral med that has the MOA of binding to PPAR gamma in adipose
tissue (increased insulin receptor numbers available)? - ANSWER: Pioglitazone
What is a SE of Pioglitazone and what is its MOA? - ANSWER: Edema (do not use in
patients with systematic HF)
What is the special alert with Pioglitazone? - ANSWER: Bladder CA, cause or
exacerbate CHF (edema), and increased risk of macula edema
What is the MOA of Acarbose? - ANSWER: alpha glucosidase inhibitor (prevents
postprandial rise of blood glucose)
