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What is the overall job of the hypothalamus?
Act as the main interface between the nervous system and the endocrine system
- regulate parasympathetic, sympathetic, and endocrine system
Clinical signs of hypothalamic pathology
Alterations in endocrine and autonomic function
- changes in metabolism, body growth, weight, temperature, appetites, sexual behavior,
developmental milestones, sleep cycles, and behavior
What are the 4 functions of the hypothalamus?
Homeostasis (hunger, thirst, sexual desire, sleep-wake cycles, etc.), endocrine control
(via pituitary), autonomic control, and limbic mechanisms
Body functions controlled by the hypothalamus
- body temperature and the febrile response
- food, salt, and water intake
- sexual cycles, sexual orientation, and onset of sexual milestones
- circadian rhythms
- body weight
- stress response
How does the hypothalamus maintain homeostasis?
Sampling blood and CSF for temperature, osmolality, hormone levels, etc.
What is the anterior limit of the hypothalamus?
, Lamina terminalis
What is the posterior limit of the hypothalamus?
Line running from the end of the mammillary bodies to the posterior commissure
Nuclei located in preoptic area of hypothalamus
Medial preoptic nucleus
Nuclei located in anterior (supraoptic) region of hypothalamus
Paraventricular nucleus, anterior nucleus, suprachiasmatic nucleus, supraoptic nucleus
Nuclei located in middle (tuberal) region of hypothalamus
Dorsomedial nucleus, ventromedial nucleus, arcuate nucleus
Nuclei located in posterior (mammillary) region of hypothalamus
Mammillary body, dorsomedial nucleus
Paraventricular nucleus
Located adjacent to 3rd ventricle, directly interfacing with endocrine and autonomic
systems
Supraoptic nucleus
Located laterally, just above the optic tract. Important for release of vasopressin (anti-
diuretic)
Suprachiasmatic nucleus
Located on midline, above optic chiasm. Responsible for generating circadian rhythms
Arcuate nucleus
Located on either side of 3rd ventricle, involved in appetite and consumption
What are the 4 major bundles of white matter associated with hypothalamus?
Fornix, mammillothalamic tract, mammillotegmental tract, medial forebrain bundle