1. Phagocytosis is dependant on: the location and the type of cells
2. Phagocytosis: A type of endocytosis in which a cell engulfs large particles or whole cells
3. Phagocytosis is dependant on the location and the type of cells, for exam- ple:: 1. neutrophils in
the bloodstream
2. Microglia or microglial cells in the brain
3. Kupffer cells in liver and spleen
4. 3 major groups of phagocytic cells: 1. neutrophils
2. the cells of the mononuclear phagocyte system, including monocytes in the blood and
macrophages derived from monocytes in the connective tissue
3. organ-specific phagocytes in the liver, spleen (Kupffer cells), lymph nodes, lungs, brain
(microglia)
5. Neutrophils are located: in the bloodstream
6. Function of neutrophils: phagocytosis
7. Microglia or microglial cells are located: in the brain
8. function of microglia or microglial cells: phagocytosis
9. Kupffer cells are located: in liver (& spleen)
10.Kupffer cells function as to remove harmful substances or cells from the
portal blood as it moves through the venous sinusoids.: phagocytes
11.Some phagoxytic cells are: specific cells that depend on the type of organ
12.In the end, all phagocytic cells: try to destroy the foreign body
13.What type of foreign bodies do phagocytic cells destroy?: They could be antigens, bacterial,
virus, infection, etc.
14.When body temperature increases we call it: a fever
15.The center for body temperature is: located at anterior hypothalamus
16.But when we have bacterial infection, the bacteria stimulates: 2 cytokines
17.2 cytokines stimulated by bacterial infection: interleukin 1 and interleukin 2
18.Interleukin 1 and interleukin 2 stimulates: a substance called arachidonic acid
19.arachidonic acid is located in: temperature center, which is at anterior hypo- thalamus
20.**Cytokines such as interleukin-1 and interleukin-2 stimulate: an enzyme called
cyclooxygenase
21.Cyclooxygenase converts: the arachidonic acid into prostaglandin E2
22.**IL1 and IL2 stimulates: the cyclooxygenase enzyme (COX-2)
23.Cyclooxygenase enzyme (COX-2) converts: the arachidonic acid into prostaglandin
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