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PRACTICAL TRANSFUSION MEDICINE FIFTH EDITION

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Practical Transfusion Medicine Practical Transfusion Medicine FIFTH EDITION Edited By Michael F. Murphy, MD, FRCP, FRCPath, FFPath Professor of Blood Transfusion Medicine University of Oxford Consultant Haematologist NHS Blood and Transplant and Department of Haematology, Oxford University Hospitals Oxford, UK David J. Roberts, MB, ChB, D.Phil, FRCPath Professor of Haematology University of Oxford Consultant Haematologist NHS Blood and Transplant and Department of Haematology, Oxford University Hospitals Oxford, UK Mark H. Yazer, MD Professor of Pathology University of Pittsburgh Adjunct Professor of Clinical Immunology University of Southern Denmark Odense, Denmark Medical Director RBC Serology Reference Laboratory, ITXM Centralized Transfusion Service Associate Medical Director ITXM Centralized Transfusion Service Pittsburgh, USA This edition first published 2017 © 2001, 2005, 2009, 2013 by John Wiley & Sons Ltd All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how to obtain permission to reuse material from this title is available at The right of Michael F. Murphy, David J. Roberts, and Mark H. Yazer to be identified as the author(s) of this has been asserted in accordance with law. Registered Offices John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, USA John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK Editorial Office 9600 Garsington Road, Oxford, OX4 2DQ, UK For details of our global editorial offices, customer services, and more information about Wiley products visit us at . Wiley also publishes its books in a variety of electronic formats and by print‐on‐demand. Some content that appears in standard print versions of this book may not be available in other formats. Limit of Liability/Disclaimer of Warranty The contents of this work are intended to further general scientific research, understanding, and discussion only and are not intended and should not be relied upon as recommending or promoting scientific method, diagnosis, or treatment by physicians for any particular patient. The publisher and the authors make no representations or warranties with respect to the accuracy and completeness of the contents of this work and specifically disclaim all warranties, including without limitation any implied warranties of fitness for a particular purpose. In view of ongoing research, equipment modifications, changes in governmental regulations, and the constant flow of information relating to the use of medicines, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each medicine, equipment, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions. Readers should consult with a specialist where appropriate. The fact that an organization or website is referred to in this work as a citation and/or potential source of further information does not mean that the authors or the publisher endorses the information the organization or website may provide or recommendations it may make. Further, readers should be aware that websites listed in this work may have changed or disappeared between when this works was written and when it is read. No warranty may be created or extended by any promotional statements for this work. Neither the publisher nor the authors shall be liable for any damages arising herefrom. Library of Congress Cataloging‐in‐Publication Data Names: Murphy, Michael F. (Michael Furber), editor. | Roberts, David J. (David John) (Consultant hematologist), editor. | Yazer, Mark H., editor. Title: Practical transfusion medicine / edited by Michael F. Murphy, David J. Roberts, Mark H. Yazer. Description: Fifth edition. | Hoboken, NJ : John Wiley & Sons Inc., 2017. | Preceded by Practical transfusion medicine / edited by Michael F. Murphy, Derwood H. Pamphilon, Nancy M. Heddle. 4th ed. 2013. | Includes bibliographical references and index. Identifiers: LCCN | ISBN 9781119129417 (cloth) | ISBN 9781119129448 (Adobe pdf) | ISBN 9781119129424 (epub) Subjects: | MESH: Blood Transfusion | Blood Grouping and Crossmatching | Hematopoietic Stem Cell Transplantation | Blood Preservation | Cross Infection–prevention & control Classification: LCC RM171 | NLM WB 356 | DDC 615.3/9–dc23 LC record available at Set in 10/12pt Warnock by SPi Global, Pondicherry, India 10 9 8 7 6 5 4 3 2 1 v List of Contributors ix Preface xv 1 Introduction: Two Centuries of Progress in Transfusion Medicine 1 Walter H. (Sunny) Dzik and Michael F. Murphy Part I Basic Principles of Immunohaematology 11 2 Essential Immunology for Transfusion Medicine 11 Jaap Jan Zwaginga and S. Marieke van Ham 3 Human Blood Group Systems 20 Geoff Daniels 4 Human Leucocyte Antigens 29 Cristina V. Navarrete and Colin J. Brown 5 Platelet and Neutrophil Antigens 43 Brian R. Curtis 6 Pretransfusion Testing and the Selection of Red Cell Products for Transfusion 58 Mark H. Yazer and Meghan Delaney Part II Complications of Transfusions 69 7 Investigation of Acute Transfusion Reactions 69 Kathryn E. Webert and Nancy M. Heddle 8 Haemolytic Transfusion Reactions 81 Edwin J. Massey, Robertson D. Davenport and Richard M. Kaufman 9 Febrile and Allergic Transfusion Reactions 97 Mark K. Fung and Nancy M. Heddle Contents vi Contents 10 Lung Injury and Pulmonary Oedema After Transfusion 108 Steven H. Kleinman and Daryl J. Kor 11 Purported Adverse Effects of ‘Old Blood’ 118 Lirong Qu and Darrell J. Triulzi 12 Transfusion‐Induced Immunomodulation 125 Amy E. Schmidt, Majed A. Refaai, Joanna M. Heal and Neil Blumberg 13 Transfusion‐Associated Graft‐Versus‐Host Disease and Microchimerism 136 Beth H. Shaz, Richard O. Francis and Christopher D. Hillyer 14 Posttransfusion Purpura 147 Michael F. Murphy 15 Transfusion‐Transmitted Infections 153 Roger Y. Dodd and Susan L. Stramer 16 Bacterial Contamination 168 Sandra Ramírez‐Arcos and Mindy Goldman 17 Emerging Infections and Transfusion Safety 176 Roger Y. Dodd Part III Practice in Blood Centres and Hospitals 184 18 Regulatory Aspects of Blood Transfusion 184 William G. Murphy, Louis M. Katz and Peter Flanagan 19 The Role of Haemovigilance in Transfusion Safety 193 Katharine A. Downes and Barbee I. Whitaker 20 Donors and Blood Collection 203 Marc Germain, Ellen McSweeney and William G. Murphy 21 Blood Donation Testing and the Safety of the Blood Supply 215 Mindy Goldman 22 Production and Storage of Blood Components 222 Marissa Li, Rebecca Cardigan, Stephen Thomas and Ralph Vassallo 23 Blood Transfusion in Hospitals 233 Erica M. Wood, Mark H. Yazer and Michael F. Murphy 24 Blood Transfusion in a Global Context 254 David J. Roberts, Alan D. Kitchen, Stephen P. Field, Imelda Bates, Jean Pierre Allain and Meghan Delaney

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,Practical Transfusion Medicine

,Practical Transfusion Medicine

FIFTH EDITION


Edited By

Michael F. Murphy, MD, FRCP, FRCPath, FFPath
Professor of Blood Transfusion Medicine
University of Oxford
Consultant Haematologist
NHS Blood and Transplant and Department of Haematology, Oxford University Hospitals
Oxford, UK
David J. Roberts, MB, ChB, D.Phil, FRCPath
Professor of Haematology
University of Oxford
Consultant Haematologist
NHS Blood and Transplant and Department of Haematology, Oxford University Hospitals
Oxford, UK
Mark H. Yazer, MD
Professor of Pathology
University of Pittsburgh
Adjunct Professor of Clinical Immunology
University of Southern Denmark
Odense, Denmark
Medical Director
RBC Serology Reference Laboratory, ITXM Centralized Transfusion Service
Associate Medical Director
ITXM Centralized Transfusion Service
Pittsburgh, USA

, This edition first published 2017

© 2001, 2005, 2009, 2013 by John Wiley & Sons Ltd

All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form
or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how
to obtain permission to reuse material from this title is available at www.wiley.com/go/permissions.

The right of Michael F. Murphy, David J. Roberts, and Mark H. Yazer to be identified as the author(s) of this has been
asserted in accordance with law.

Registered Offices
John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, USA
John Wiley & Sons Ltd, The Atrium, Southern Gate, Chichester, West Sussex, PO19 8SQ, UK

Editorial Office
9600 Garsington Road, Oxford, OX4 2DQ, UK
For details of our global editorial offices, customer services, and more information about Wiley products visit us
at www.wiley.com.

Wiley also publishes its books in a variety of electronic formats and by print‐on‐demand. Some content that appears in
standard print versions of this book may not be available in other formats.

Limit of Liability/Disclaimer of Warranty

The contents of this work are intended to further general scientific research, understanding, and discussion only and are
not intended and should not be relied upon as recommending or promoting scientific method, diagnosis, or treatment by
physicians for any particular patient. The publisher and the authors make no representations or warranties with respect
to the accuracy and completeness of the contents of this work and specifically disclaim all warranties, including without
limitation any implied warranties of fitness for a particular purpose. In view of ongoing research, equipment modifications,
changes in governmental regulations, and the constant flow of information relating to the use of medicines, equipment,
and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for
each medicine, equipment, or device for, among other things, any changes in the instructions or indication of usage and for
added warnings and precautions. Readers should consult with a specialist where appropriate. The fact that an organization
or website is referred to in this work as a citation and/or potential source of further information does not mean that the
authors or the publisher endorses the information the organization or website may provide or recommendations it may
make. Further, readers should be aware that websites listed in this work may have changed or disappeared between when
this works was written and when it is read. No warranty may be created or extended by any promotional statements for this
work. Neither the publisher nor the authors shall be liable for any damages arising herefrom.

Library of Congress Cataloging‐in‐Publication Data
Names: Murphy, Michael F. (Michael Furber), editor. | Roberts, David J. (David John)
(Consultant hematologist), editor. | Yazer, Mark H., editor.
Title: Practical transfusion medicine / edited by Michael F. Murphy, David J. Roberts, Mark H. Yazer.
Description: Fifth edition. | Hoboken, NJ : John Wiley & Sons Inc., 2017. |
Preceded by Practical transfusion medicine / edited by Michael F. Murphy,
Derwood H. Pamphilon, Nancy M. Heddle. 4th ed. 2013. |
Includes bibliographical references and index.
Identifiers: LCCN 2016053360 | ISBN 9781119129417 (cloth) | ISBN 9781119129448 (Adobe pdf ) |
ISBN 9781119129424 (epub)
Subjects: | MESH: Blood Transfusion | Blood Grouping and Crossmatching |
Hematopoietic Stem Cell Transplantation | Blood Preservation |
Cross Infection–prevention & control
Classification: LCC RM171 | NLM WB 356 | DDC 615.3/9–dc23
LC record available at https://lccn.loc.gov/2016053360

Set in 10/12pt Warnock by SPi Global, Pondicherry, India



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