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Who should undergo annual lung cancer screening with low-dose computed
tomography (LDCT)?
adults aged 50 to 80 years who have a 20 pack-year smoking history and currently
smoke or have quit within the past 15 years
When should lung cancer screening be discontinued?
once a person has not smoked for 15 years or develops a health problem that
substantially limits life expectancy or the ability or willingness to have curative lung
surgery
How are pack years calculated?
number of packs smoked per day multiplied by the number of years smoked
What is another name for a solitary pulmonary nodule?
coin lesions
How do solitary pulmonary nodules appear on chest imaging?
- <3 cm, isolated, round opacity
- well-defined, outlined by normal lung parenchyma
- not associated with infiltrate, atelectasis, or adenopathy
How are solitary nodules classified?
solid or subsolid based on CT appearance
How are subsolid nodules divided?
pure ground-glass nodules (no solid component) and part-solid nodules (ground-glass
and solid components)
Why are subsolid nodules important?
may represent adenocarcinoma or its precursors
What are the symptoms of solitary pulmonary nodules?
asymptomatic and incidental finding
Describe the risk of malignancy associated with solitary pulmonary nodules.
- incidence of malignancy increases with age, smoking, and past history of malignancy
- larger lesions (>2cm) are more likely to be malignant
What type of scan should be obtained if solitary pulmonary nodules are
suspected?
non-contrast CT
When should solitary pulmonary nodules be treated?
- if low risk, watch
- if intermediate risk, potentially biopsy
- if high risk, resect following staging
What are the methods of biopsy in solitary pulmonary nodules?
transthoracic needle aspiration (TTNA) and bronchoscopy
What is the purpose of PET scans for solitary pulmonary nodules?
detect malignant lesions with high sensitivity and specificity
Who is sputum cytology used for in solitary pulmonary nodules?
bad surgical candidates