Clinical Chem Test
Bank 24/25 (Final
Exam)
, In which of the following disorders would the maternal serum level of 1-
fetoprotein be elevated?
A. Neural tube defect.
B. Cardiac ischemia.
C. Down syndrome.
D. Small cell lung carcinoma - CORRECT ANSWERSA. Neural tube defect
Which of the following is FALSE about PSA?
A. It is a single-chain glycoprotein
B. It is used as a tumor marker
C. It is not elevated in benign prostatic hyperplasia
D. It is quantified in serum by immunoassays - CORRECT ANSWERSC. It is not
elevated in benign prostatic hyperplasia.
Which of the following biomarkers is elevated in nonmucinous epithelial ovarian
cancer?
A. CA 15-3
B. CA 19-9
C. CA 125
D. CEA - CORRECT ANSWERSC. CA 125
Which of the following is a sialylated Lewis blood group antigen associated with
colorectal cancer?
A. CA 125
B. CA 15-3
C. PSA
D. CA 19-9 - CORRECT ANSWERSD. CA 19-9
Which of the following biomarkers are elevated in advanced stages of breast
cancer?
A. Total and free PSA
B. CEA and alpha-fetoprotein
C. CA 15-3 and CA 549
D. DUPAN-2 and Gastrin - CORRECT ANSWERSC. CA 15-3 and CA 549
Which tumor marker is associated with cancer of the urinary bladder?
A. CA 125
B. CA19-9
C. CA 50
, D. Nuclear matrix protein - CORRECT ANSWERSD. Nuclear matrix protein
What is the primary clinical usefulness of measuring carcinoembryonic antigen?
A. Diagnosis of lung cancer
B. Diagnosis of colorectal cancer
C. Screening for breast cancer
D. Monitoring for recurrence of colon cancer - CORRECT ANSWERSD.
Monitoring for recurrence of colon cancer
Which of the following is used to assess the usefulness of trastuzumab
(Herceptin®) therapy for breast cancer?
A. CA 15-3
B. HER-2/neu
C. CA 125
D. Prolactin - CORRECT ANSWERSB. HER-2/neu
9. Which type of hCG test would be most useful to assess a person suspected of
having testicular cancer?
A. Plasma immunoassay for intact hCG and the β-hCG subunits
B. Plasma immunoassay fro the free alpha and β-hCG subunits
C. Urine assay for hCG-β core
D. Plasma immunoassay for intact hCG only - CORRECT ANSWERSA. Plasma
immunoassay for intact hCG and the β-hCG subunits
A markedly elevated serum AFP is associated with which of the following?
A. Ovarian cancer
B. Lung cancer
C. Hepatoma
D. Breast cancer - CORRECT ANSWERSC. Hepatoma
Which of the following assays is recommended as a screening test for colorectal
cancer in persons over 50 years of age?
A. Fecal typsin
B. AFP
C. BTA
D. Occult blood t test - CORRECT ANSWERSD. Occult blood test
Which of the following must be determined to calculate diagnostic specificity?
A. True-negatives and false-positives
B. True-positives and false-positives
Bank 24/25 (Final
Exam)
, In which of the following disorders would the maternal serum level of 1-
fetoprotein be elevated?
A. Neural tube defect.
B. Cardiac ischemia.
C. Down syndrome.
D. Small cell lung carcinoma - CORRECT ANSWERSA. Neural tube defect
Which of the following is FALSE about PSA?
A. It is a single-chain glycoprotein
B. It is used as a tumor marker
C. It is not elevated in benign prostatic hyperplasia
D. It is quantified in serum by immunoassays - CORRECT ANSWERSC. It is not
elevated in benign prostatic hyperplasia.
Which of the following biomarkers is elevated in nonmucinous epithelial ovarian
cancer?
A. CA 15-3
B. CA 19-9
C. CA 125
D. CEA - CORRECT ANSWERSC. CA 125
Which of the following is a sialylated Lewis blood group antigen associated with
colorectal cancer?
A. CA 125
B. CA 15-3
C. PSA
D. CA 19-9 - CORRECT ANSWERSD. CA 19-9
Which of the following biomarkers are elevated in advanced stages of breast
cancer?
A. Total and free PSA
B. CEA and alpha-fetoprotein
C. CA 15-3 and CA 549
D. DUPAN-2 and Gastrin - CORRECT ANSWERSC. CA 15-3 and CA 549
Which tumor marker is associated with cancer of the urinary bladder?
A. CA 125
B. CA19-9
C. CA 50
, D. Nuclear matrix protein - CORRECT ANSWERSD. Nuclear matrix protein
What is the primary clinical usefulness of measuring carcinoembryonic antigen?
A. Diagnosis of lung cancer
B. Diagnosis of colorectal cancer
C. Screening for breast cancer
D. Monitoring for recurrence of colon cancer - CORRECT ANSWERSD.
Monitoring for recurrence of colon cancer
Which of the following is used to assess the usefulness of trastuzumab
(Herceptin®) therapy for breast cancer?
A. CA 15-3
B. HER-2/neu
C. CA 125
D. Prolactin - CORRECT ANSWERSB. HER-2/neu
9. Which type of hCG test would be most useful to assess a person suspected of
having testicular cancer?
A. Plasma immunoassay for intact hCG and the β-hCG subunits
B. Plasma immunoassay fro the free alpha and β-hCG subunits
C. Urine assay for hCG-β core
D. Plasma immunoassay for intact hCG only - CORRECT ANSWERSA. Plasma
immunoassay for intact hCG and the β-hCG subunits
A markedly elevated serum AFP is associated with which of the following?
A. Ovarian cancer
B. Lung cancer
C. Hepatoma
D. Breast cancer - CORRECT ANSWERSC. Hepatoma
Which of the following assays is recommended as a screening test for colorectal
cancer in persons over 50 years of age?
A. Fecal typsin
B. AFP
C. BTA
D. Occult blood t test - CORRECT ANSWERSD. Occult blood test
Which of the following must be determined to calculate diagnostic specificity?
A. True-negatives and false-positives
B. True-positives and false-positives
