Pharmacology III - Exam #3 with Verified Answers
1. What are the CDC's classifications for resistance 1. Urgent threats
threats? (4) 2. Serious threats
3. Concerning
threats
4. Watch list
2. Explain the "innovation gap" of new antibiotics a period of time
where no new
classes of antibi-
otics were discov-
ered. This likely
stemmed from an
abundance of ef-
fective antibiotics
available in the
1960's and 1970's
3. Classification of antibiotics is based on... (3) 1. Class and spec-
trum of microor-
ganisms it kills
2. Biochemical
pathway it targets
3. Chemical struc-
ture of its pharma-
cophore
4. Bacteriostatic antibiotics that
inhibit bacterial
growth
, Pharmacology III - Exam #3 with Verified Answers
5. Bactericidal antibiotics that
cause bacterial cell
death
6. MBC/MIC > for a bacteriostatic drug 4
7. Gram-negative bacteria cell wall component(s) (4) 1. Inner membrane
2. Peptidoglycan
3. Outer membrane
4. Lipopolysaccha-
ride (endotoxin; ex.
PAMPS)
8. Gram-positive bacteria cell wall component(s) (2) 1. Single plas-
ma member en-
cased by thick lay-
ers of peptidogly-
can cross linked by
amino acids
2. Stabilized by Te-
ichoic and Lipotei-
choic acids
9. Gram-negative bacteria stain... pink/red
10. Gram-positive bacteria stain... purple
, Pharmacology III - Exam #3 with Verified Answers
11. What part of the human body contains the largest Large intestine
concentration of microbes?
12. Staphylococci gram-positive cocci
in clusters (purple)
13. List the two discussed Staphylococci bacterial Staphylococcus
species aureus and
Staphylococcus
epidermidis
14. List some key points for Staphylococcus aureus (4) 1. Primarily a hu-
man pathogen
2. Causes numer-
ous infections
3. Multi-drug resis-
tant
4. High morbidity
and mortality
15. Hospital-associated methicillin-resistant Staphylo- 1. Multi-drug resis-
coccus aureus (HA-MRSA) key points (5) tant
2. Variety of infec-
tion types
3. Invades at-risk
population
4. Reduced "fit-
ness"
1. What are the CDC's classifications for resistance 1. Urgent threats
threats? (4) 2. Serious threats
3. Concerning
threats
4. Watch list
2. Explain the "innovation gap" of new antibiotics a period of time
where no new
classes of antibi-
otics were discov-
ered. This likely
stemmed from an
abundance of ef-
fective antibiotics
available in the
1960's and 1970's
3. Classification of antibiotics is based on... (3) 1. Class and spec-
trum of microor-
ganisms it kills
2. Biochemical
pathway it targets
3. Chemical struc-
ture of its pharma-
cophore
4. Bacteriostatic antibiotics that
inhibit bacterial
growth
, Pharmacology III - Exam #3 with Verified Answers
5. Bactericidal antibiotics that
cause bacterial cell
death
6. MBC/MIC > for a bacteriostatic drug 4
7. Gram-negative bacteria cell wall component(s) (4) 1. Inner membrane
2. Peptidoglycan
3. Outer membrane
4. Lipopolysaccha-
ride (endotoxin; ex.
PAMPS)
8. Gram-positive bacteria cell wall component(s) (2) 1. Single plas-
ma member en-
cased by thick lay-
ers of peptidogly-
can cross linked by
amino acids
2. Stabilized by Te-
ichoic and Lipotei-
choic acids
9. Gram-negative bacteria stain... pink/red
10. Gram-positive bacteria stain... purple
, Pharmacology III - Exam #3 with Verified Answers
11. What part of the human body contains the largest Large intestine
concentration of microbes?
12. Staphylococci gram-positive cocci
in clusters (purple)
13. List the two discussed Staphylococci bacterial Staphylococcus
species aureus and
Staphylococcus
epidermidis
14. List some key points for Staphylococcus aureus (4) 1. Primarily a hu-
man pathogen
2. Causes numer-
ous infections
3. Multi-drug resis-
tant
4. High morbidity
and mortality
15. Hospital-associated methicillin-resistant Staphylo- 1. Multi-drug resis-
coccus aureus (HA-MRSA) key points (5) tant
2. Variety of infec-
tion types
3. Invades at-risk
population
4. Reduced "fit-
ness"
