GMS6552 EXAM QUESTIONS AND ANSWERS WITH COMPLETE
SOLUTIONS VERIFIED
What is the relationship between oncogenes and proto-oncogenes?
Proto-oncogenes become oncogenes during carcinogenesis
Which form(s) of oncogene activation involve(s) a mechanism that will
NEVERdirectly change the DNA sequence in a cell? Choose all that apply.
Hypomethylation
Does the presence of oncogenes make it harder or easier to develop selective
anti-cancer agents with fewer side effects?
Easier
What is the relationship between Ras and Myc mutations in cancer?
Myc mutations increase the lethality of Ras inhibitors.
What is the effect of one cycle of the sodium potassium pump in cells?
3 sodium ions out, 2 potassium ions in
The resting membrane potential of a neuron is _____.
-90 mV
If you are measuring the voltage across a cell membrane and place one electrode
just outside of the membrane, in which location should you place the other
electrode in order to measure the greatest voltage difference?
Intracellularly, near the membrane
, What is the relationship between conductance across a membrane and the
number of channels that are open in that membrane?
Conductance is proportional to the number of receptors
Which single-channel patch clamp technique mimics a scenario where the void of
the needle serves as the "inside" of the cell and the solution the tip of the needle
is placed into serves as the "outside?"
Outside out recording
What is the mechanism by which voltage-gated channels open in response to
voltage changes?
Charged residues in the channel lead to a conformation change
The voltage-clamp technique is uniquely able to keep which variable constant?
(Em - Erev)
Two neurons show the same current flow upon activation in response to the
same stimulus. If neuron A has channels that stay open longer, which situation
would explain how the two neurons achieve equal current?
Neuron B has more channels
Though which mechanism is glutamate signaling stopped?
Re-uptake of glutamate
Hyperpolarization following an action potential induced by ACh administration is
primarily caused by activation of which receptors?
mAChR
Which ion channels may serve as pharmacological targets for treating epilepsy?
Voltage-gated channels, GABA receptors, Glutamate receptors, Calcium channels
SOLUTIONS VERIFIED
What is the relationship between oncogenes and proto-oncogenes?
Proto-oncogenes become oncogenes during carcinogenesis
Which form(s) of oncogene activation involve(s) a mechanism that will
NEVERdirectly change the DNA sequence in a cell? Choose all that apply.
Hypomethylation
Does the presence of oncogenes make it harder or easier to develop selective
anti-cancer agents with fewer side effects?
Easier
What is the relationship between Ras and Myc mutations in cancer?
Myc mutations increase the lethality of Ras inhibitors.
What is the effect of one cycle of the sodium potassium pump in cells?
3 sodium ions out, 2 potassium ions in
The resting membrane potential of a neuron is _____.
-90 mV
If you are measuring the voltage across a cell membrane and place one electrode
just outside of the membrane, in which location should you place the other
electrode in order to measure the greatest voltage difference?
Intracellularly, near the membrane
, What is the relationship between conductance across a membrane and the
number of channels that are open in that membrane?
Conductance is proportional to the number of receptors
Which single-channel patch clamp technique mimics a scenario where the void of
the needle serves as the "inside" of the cell and the solution the tip of the needle
is placed into serves as the "outside?"
Outside out recording
What is the mechanism by which voltage-gated channels open in response to
voltage changes?
Charged residues in the channel lead to a conformation change
The voltage-clamp technique is uniquely able to keep which variable constant?
(Em - Erev)
Two neurons show the same current flow upon activation in response to the
same stimulus. If neuron A has channels that stay open longer, which situation
would explain how the two neurons achieve equal current?
Neuron B has more channels
Though which mechanism is glutamate signaling stopped?
Re-uptake of glutamate
Hyperpolarization following an action potential induced by ACh administration is
primarily caused by activation of which receptors?
mAChR
Which ion channels may serve as pharmacological targets for treating epilepsy?
Voltage-gated channels, GABA receptors, Glutamate receptors, Calcium channels
