GMS6552: NFKB-APOPTOSIS EXAM QUESTIONS AND
ANSWERS WITH COMPLETE SOLUTIONS VERIFIED
receptor signaling to NF-kB
-canonical pathway
-non-canonical pathway
canonical pathway
-first to be discovered
-considered primary pathway
-rapid and transient
-independent of protein synthesis
-respond to numerous stimuli
-diverse functions
noncanonical pathway
-slow and persistent (long-lasting effects)
-dependent on protein synthesis
-respond to a subset of TNFR signals
-specific functions
who/when was NF-kB discovered?
-mid 80s by David Baltimore
NF-kB
, -factor in the nucleus of B cells that binds to the enhancer of kappa light chain of
immunoglobulin
activation of NF-kB
-cytokines (TNF family, IL-1, IL-17, IL-18)
-endotoxin (LPS)
-viruses (DNA, RNA)
-apoptosis-inducers (chemotherapeutics, radiation)
-carcinogens
-tumor promoters (phorbol esters, okadaic acid)
-stress (pH, hypoxia, heavy metals)
-ROS (reactive oxygen species)
outcomes of NF-kB activation
-inflammation (cytokine/chemokine production)
-lymphoid organogenesis
-B cell survival and maturation
-bone metabolism
-angiogenesis (VEGF production)
-metastasis (adhesion molecules)
-tumor production (COX-2, iNOS, MMPs)
-proliferation
-survival/anti-apoptosis (bcl-xl, cIAP, XIAP, cFLIP)
TLRs
ANSWERS WITH COMPLETE SOLUTIONS VERIFIED
receptor signaling to NF-kB
-canonical pathway
-non-canonical pathway
canonical pathway
-first to be discovered
-considered primary pathway
-rapid and transient
-independent of protein synthesis
-respond to numerous stimuli
-diverse functions
noncanonical pathway
-slow and persistent (long-lasting effects)
-dependent on protein synthesis
-respond to a subset of TNFR signals
-specific functions
who/when was NF-kB discovered?
-mid 80s by David Baltimore
NF-kB
, -factor in the nucleus of B cells that binds to the enhancer of kappa light chain of
immunoglobulin
activation of NF-kB
-cytokines (TNF family, IL-1, IL-17, IL-18)
-endotoxin (LPS)
-viruses (DNA, RNA)
-apoptosis-inducers (chemotherapeutics, radiation)
-carcinogens
-tumor promoters (phorbol esters, okadaic acid)
-stress (pH, hypoxia, heavy metals)
-ROS (reactive oxygen species)
outcomes of NF-kB activation
-inflammation (cytokine/chemokine production)
-lymphoid organogenesis
-B cell survival and maturation
-bone metabolism
-angiogenesis (VEGF production)
-metastasis (adhesion molecules)
-tumor production (COX-2, iNOS, MMPs)
-proliferation
-survival/anti-apoptosis (bcl-xl, cIAP, XIAP, cFLIP)
TLRs
