GMS6504 EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED

GMS6504 EXAM QUESTIONS AND ANSWERS WITH COMPLETE

SOLUTIONS VERIFIED


which of the following would best be described as a system independent

parameter determining pharmacological response?



•the number of receptors present

•the cellular cascade

•pharmacokinetics

•receptor affinity for the ligand

•presence of an antagonist

receptor affinity for the ligand

when taking a natural agonist and converting it to an antagonist using synthetic

chemistry, what are the desired effects on affinity and efficacy?



•both increase

•both decrease

•affinity increases, efficacy decreases

•affinity decreases, efficacy increases

affinity increases, efficacy decreases

in the langmuir equation, which variable represents the proportion of receptors

that are bound by ligand?

,•r

•D

•Kd

•Rt

•DR

r

if a ligand has an intrinsic activity, alpha, of 0.54, this ligand is best considered

a...



•full agonist

•partial agonist

•antagonist

•inverse agonist

partial agonist

if you do a cell culture experiment where you exogenously express a receptor in

cells, which variable in the equation R=f[alpha•r•Rt] are you most directly

controlling?



•R

•f

•alpha

, •r

•Rt

Rt

with an efficacy driven agonist, reducing the number of receptors present will

shift the response curve...



•up

•down

•left

•right

•not at all

right

applying the two state theory of receptors to an ion channel, which state[s] would

be active? select all that apply.



•Rclosed

•Ropen

•ARclosed

•ARopen

•none would be active

•Ropen

•ARopen