+ GRADED
Pharamacokinetics
drug movement throughout the body; how the body deal with medications; absorption,
distribution, metabolism, and excretion
Pharmacodynamics
how a medicine changes the body
Therapeutic class
therapeutic usefulness in treating a particular disease or disorder
Pharmacological Class
The way a drug works at the molecular, tissue, or body system level
Prototypes
well-understood drug model with which other drugs in its representative class are
compared
Chemical name
assigned using standard nomenclature established; a drug has only 1 chemical name
Generic name
active ingredients in a drug; usually lowercase name assigned by the manufacturer who
first develops a drug; it is often derived from the chemical name;
Trade name
The commercial name given to a drug product by its manufacturer; capitalized
Metabolism
biotransformation; process of chemically converting a drug to a form that is usually more
easily removed from the body; liver is the primary site
Extretion
drugs are removed from the body; the rate is a primary determinant of the concentration
of the drugs in the bloodstream and tissues; is important because the concentration of
drugs in the bloodstream determines their duration of action; primary site is the kidneys;
factors affecting drug excretion include liver or kidney impairment, blood flow, degree of
ionization of the drug, lipid solubility of the drug, drug-protein complexes, metabolic
activity, pH, respiratory/grandular/biliary activity
Absorption
process involving the movement of a substance from its site of administration, across
body membrane, to circulating fluids; primary factor determine the length of time it takes
a drug to produce its effect; affected by drug formulation, dose, route of administration,
size of the drug molecule, surface area of the absorptive site, digestive motility, blood
flow, and lipid solubility of the drug
Distribution
the transport of drug throughout the body after they have been absorbed or injected
Half-life
the length of time required for a medication's plasma concentration to decrease to one-
half after administration; the longer it takes a medication to be excreted, the greater the
half life; half-life will increase with extensive kidney or liver disease
Peak