ATI Pharmacology COMPREHENSIVE
QUESTIONS WITH CORRECT ANSWERS 2024
EDITION/ 100% GUARANTEED PASS
_________ dysfunction will cause drugs to accumulate in the body
Common tests to check _________ function include BUN (blood urine nitrogen)
and creatinine clearance - ANSWER Renal
The nurse gives a medication to a patient with a history of liver disease. The nurse
will monitor this patient for
a. decrease drug effects
b. increased drug effects
c. decreased therapeutic range
d. increase therapeutic range - ANSWER decrease drug effects
______ is the primary site of metabolism - ANSWER Liver
A staff educator is reviewing medication dosages and factors that influence
medication metabolism with a group of nurses at an in-service presentation.
Which of the following factors should the educator include as a reason to
administer lower medication dosages? - ANSWER Liver failure
drug attaches to _______ then will enter bloodstream slowly throughout the day -
ANSWER protein
The nurse is administering 2 drugs to a patient and learns that both drugs are
highly protein bound. The nurse may expect
Decreased bioavailability
Decrease drug effect
Decreased drug interactions
Increased risk of adverse effects - ANSWER Increased risk of adverse effects
If a medication is highly protein bound, a patient that is malnourished and has low
protein levels may be at risk of experiencing drug effects. - ANSWER True
alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline
phosphatase (ALP), albumin, and bilirubin tests. The ALT and AST tests measure
, enzymes that your liver releases in response to damage or disease - ANSWER liver
function tests
Period of time required for the concentration or amount of drug in the body to be
reduced by one half.
A drug's plasma half life depends on how quickly the drug is eliminated from the
plasma Matters because it can build up in the body - ANSWER Half life
is the lowest concentration in the patient's bloodstream. This should be collected
just prior to administration of the drug - ANSWER trough level
is the highest concentration of a drug in the patient's bloodstream - ANSWER
peak level
Metabolism effects _________
People with drug abuse have a higher _________ to certain medications because
they have abused the drug - ANSWER tolerance
Used when a rapid clinical response is necessary, e.g., an acute asthmatic episode.
This route allows one to achieve relatively precise drug concentrations in the
plasma, since bioavailability is not a concern. Most drugs should be injected over
1-2 minutes in order to prevent the occurrence of very high drug concentrations
in the injected vein, possibly causing adverse effects. Some drugs, particularly
those with narrow therapeutic indices or short half-lives, are best administered as
a slow ____ infusion or drip. - ANSWER IV
By far the most common route. The passage of drug from the gut into the blood is
influenced by biologic and physicochemical factors (discussed in detail below),
and by the dosage form. For most drugs, two- to five-fold differences in the rate
or extent of gastrointestinal absorption can occur, depending on the dosage form.
These two characteristics, rate and completeness of absorption, comprise
bioavailability. Generally, the bioavailability of oral drugs follows the order:
solution > suspension > capsule > tablet > coated tablet. - ANSWER oral (PO)
Some drugs, notably insulin, are routinely administered SC. Drug absorption is
generally slower SC than IM, due to poorer vascularity. Absorption can be
facilitated by heat, massage or vasodilators. It can be slowed by coadministration
QUESTIONS WITH CORRECT ANSWERS 2024
EDITION/ 100% GUARANTEED PASS
_________ dysfunction will cause drugs to accumulate in the body
Common tests to check _________ function include BUN (blood urine nitrogen)
and creatinine clearance - ANSWER Renal
The nurse gives a medication to a patient with a history of liver disease. The nurse
will monitor this patient for
a. decrease drug effects
b. increased drug effects
c. decreased therapeutic range
d. increase therapeutic range - ANSWER decrease drug effects
______ is the primary site of metabolism - ANSWER Liver
A staff educator is reviewing medication dosages and factors that influence
medication metabolism with a group of nurses at an in-service presentation.
Which of the following factors should the educator include as a reason to
administer lower medication dosages? - ANSWER Liver failure
drug attaches to _______ then will enter bloodstream slowly throughout the day -
ANSWER protein
The nurse is administering 2 drugs to a patient and learns that both drugs are
highly protein bound. The nurse may expect
Decreased bioavailability
Decrease drug effect
Decreased drug interactions
Increased risk of adverse effects - ANSWER Increased risk of adverse effects
If a medication is highly protein bound, a patient that is malnourished and has low
protein levels may be at risk of experiencing drug effects. - ANSWER True
alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline
phosphatase (ALP), albumin, and bilirubin tests. The ALT and AST tests measure
, enzymes that your liver releases in response to damage or disease - ANSWER liver
function tests
Period of time required for the concentration or amount of drug in the body to be
reduced by one half.
A drug's plasma half life depends on how quickly the drug is eliminated from the
plasma Matters because it can build up in the body - ANSWER Half life
is the lowest concentration in the patient's bloodstream. This should be collected
just prior to administration of the drug - ANSWER trough level
is the highest concentration of a drug in the patient's bloodstream - ANSWER
peak level
Metabolism effects _________
People with drug abuse have a higher _________ to certain medications because
they have abused the drug - ANSWER tolerance
Used when a rapid clinical response is necessary, e.g., an acute asthmatic episode.
This route allows one to achieve relatively precise drug concentrations in the
plasma, since bioavailability is not a concern. Most drugs should be injected over
1-2 minutes in order to prevent the occurrence of very high drug concentrations
in the injected vein, possibly causing adverse effects. Some drugs, particularly
those with narrow therapeutic indices or short half-lives, are best administered as
a slow ____ infusion or drip. - ANSWER IV
By far the most common route. The passage of drug from the gut into the blood is
influenced by biologic and physicochemical factors (discussed in detail below),
and by the dosage form. For most drugs, two- to five-fold differences in the rate
or extent of gastrointestinal absorption can occur, depending on the dosage form.
These two characteristics, rate and completeness of absorption, comprise
bioavailability. Generally, the bioavailability of oral drugs follows the order:
solution > suspension > capsule > tablet > coated tablet. - ANSWER oral (PO)
Some drugs, notably insulin, are routinely administered SC. Drug absorption is
generally slower SC than IM, due to poorer vascularity. Absorption can be
facilitated by heat, massage or vasodilators. It can be slowed by coadministration
