GMS 6530 HYPERLIPIDEMIA EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED

GMS 6530 HYPERLIPIDEMIA EXAM QUESTIONS AND ANSWERS

WITH COMPLETE SOLUTIONS VERIFIED

Chylomicrons

- largest

- mostly triglycerides

- short life span

- broke down by LPL

VLDL

- mostly triglycerides

IDL

- cholesterol

- triglycerides

LDL

- cholesterol

- bad

HDL

- apolipoproteins

- little cholesterol

- good

LPL

, - lipoprotein lipase

- breaks down lipoproteins into free fatty acids

- lowers triglyceride levels

LDL receptors

- decrease with age

- located in liver

- control plasma cholesterol levels

Statins

- HMG-coA reductase inhibitors

- or's & ol's

- reduce cholesterol synthesis

- most effective in reducing LDL

- work in hepatocytes

Statins indirect action

- increase LDL receptors > increasing extraction of LDL by liver, decreasing plasma

concentration

- small decrease in VLDL (triglycerides) & HDL

-

Statin use

- hypercholesterolemia (increased LDL)

- mixed hyperlipidemia (increased LDL & VLDL)

- first line after MI

Statin side effects