GMS6530 FINAL DRUGS EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS GRADED A++

GMS6530 FINAL DRUGS EXAM QUESTIONS AND ANSWERS

WITH COMPLETE SOLUTIONS GRADED A++


nitroglycerin, isosorbide mono- and dinitrate targets

blood vessels

nitroglycerin, isosorbide mono- and dinitrate mechanism

- vasodilator (veins>arterioles)

- decrease: preload, congestion, blood pressure

- decrease O2 demand; increase O2 supply

hydralazine, minoxidil target

blood vessels

hydralazine, minoxidil mechanism

- vasodilator (arterioles>veins)

- decrease: peripheral resistance, blood pressure, afterload

- increase: stroke volume

- decrease intracellular Ca2+, increase K+ channel

sodium nitroprusside target

blood vessels

sodium nitroprusside mechanism

- vasodilator (veins=arterioles)

- decrease: peripheral resistance, blood pressure, cardiac output

mannitol mechanism

, - osmosis

- increase plasma osmolarity, decrease water reabsorption in PCT

sacubitril target

- angiotensin receptor neprilysin

sacubitril mechanism

- inhibit breakdown of ANP, BNP, Bradykinin and Adrenomedullin

- increased vasodilatory, diuretic, and natriuretic effects

acetazolamide target

carbonic anhydrase

acetazolamide mechanism

- directly inhibits reabsorption of HCO3-

- indirectly inhibits reabsorption of Na+

heparin target

antithrombin III

heparin mechanism

- activates antithrombin III to inhibits factor Xa

- immediate anticoagulation

LMHW target

antithrombin III

LMWH mechanism

- activates antithrombin III to inhibit thrombin, factor IXa, Xa, XIa

- immediate anticoagulation

amicar target