GMS6540 EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS VERIFIED

GMS6540 EXAM QUESTIONS AND ANSWERS WITH COMPLETE

SOLUTIONS VERIFIED

Phase-nonspecific drugs

alkylating agents (cyclophosphamide), cross-linkers (cysplatin), topoisomerase

inhibitors (doxorubicin)

Antimetabolites

work in "S" phase, 5-FU, Methotrexate, cytosine arabinoside

Microtubule drugs

works on "M" phase, paclitaxel, vincristin

Common chemotherapy toxicities

myelosuppression, mucositis, alopecia, Teratogenicity, second malignancies

Drug that causes temporary or permanent sterility and hemorrhagic cystitis

cyclophosphamide

Drugs that cause neurotoxicity

vincristine, paclitaxel, cisplatin

Drug that causes cardiotoxicity

Doxorubicin

Drug that causes pulmonary fibrosis

Bleomycin

Cyclophosphamide

- Cross links DNA strands to block replication and trigger death

- myelosuppression, 2nd malignancies, sterility, and hemorrhagic cystitis

, Cisplatin

-Cross links DNA strands to block replication and trigger death

- Severe renal toxicity (dose limiting), peripheral neuropathy, LOW myleosuppression

Bleomycin

-Binds DNA and generates free radicals that cause breaks in DNA

-pulmonary fibrosis, erythema, LOW myleosuppression

Topotecan

-Traps topo I-DNA complex, resulting in formation of DNA strand breaks

- high myleosuppression

Doxorubicin/Etoposide

- traps enzyme-DNA complex in topo-II resulting in the formation of DNA breaks

- high myleosuppression, dose-related cardiotoxicity

Paclitaxol

- Binds tubulin, blocks disassembly

- neurotoxic, Myelosuppression

Vincristine

- Binds tubulin, blocks assembly

- neurotoxic, LOW myelosuppression

Methotrexate

- Inhibits dihydrofolate reductase (DHFR), blocking synthesis or thymidine and purines

- myelosuppression and mucositis

5-FU