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GMS6540 - ALL DRUGS EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS GRADED A++

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GMS6540 - ALL DRUGS EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS GRADED A++ MODULE 2 DNA damaging drugs (2) Cyclophosphamide (DNA alkylating agent) Cisplatin Topoisomerase II drugs (2) Doxorubicin, Etoposide Microtubule drugs (2) Vincristine Paclitaxel Antimetabolites (3) Methotrexate5-Fluorouracil (5-FU)Cytosine arabinoside (Ara C) Protein tyrosine kinase inhibitors (1) Imatinib Cyclophosphamide mechanism Alkalating agent; DNA cross links Haemorrhagic cystitis, Myelosuppression, and secondary malignancies Cisplatin Mechanism DNA cross-link Neuro and renal toxicity Bleomycin Mechanism Free radicals -- DNA breaks Pulmonary fibrosis Topotecan Mechanism Topoisomerase I inhibitor Myelosuppression Doxorubicin Mechanism Topoisomerase inhibitor II Myelosuppression and Cardiotoxicity Etoposide Mechanism Topoisomerase inhibitor II Myelosuppression Paclitaxel Microtubule stabilization Neurotoxicity, myelosuppression Vincristine Mechanism Disruption of microtubules Neurotoxicity Methotrexate Mechanism Folate synthesis inhibitor (DHFR) Myelosuppression and Mucositis F-Fluorouracil Mechanism Folate synthesis inhibitor (TS) Myelosuppression and Mucositis Cytarabine Mechanism Inhibit DNA elongations Myelosuppression MODULE 3 Targeted Therapy EGFR Antibodies (6)

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GMS6540 - ALL DRUGS EXAM QUESTIONS AND ANSWERS

WITH COMPLETE SOLUTIONS GRADED A++

MODULE 2

DNA damaging drugs (2)

Cyclophosphamide (DNA alkylating agent)

Cisplatin

Topoisomerase II drugs (2)

Doxorubicin, Etoposide

Microtubule drugs (2)

Vincristine

Paclitaxel

Antimetabolites (3)

Methotrexate5-Fluorouracil (5-FU)Cytosine arabinoside (Ara C)

Protein tyrosine kinase inhibitors (1)

Imatinib

Cyclophosphamide mechanism

Alkalating agent; DNA cross links

Haemorrhagic cystitis, Myelosuppression, and secondary malignancies

,Cisplatin Mechanism

DNA cross-link

Neuro and renal toxicity

Bleomycin Mechanism

Free radicals --> DNA breaks

Pulmonary fibrosis

Topotecan Mechanism

Topoisomerase I inhibitor

Myelosuppression

Doxorubicin Mechanism

Topoisomerase inhibitor II

Myelosuppression and Cardiotoxicity

Etoposide Mechanism

Topoisomerase inhibitor II

Myelosuppression

Paclitaxel

,Microtubule stabilization

Neurotoxicity, myelosuppression

Vincristine Mechanism

Disruption of microtubules

Neurotoxicity

Methotrexate Mechanism

Folate synthesis inhibitor (DHFR)

Myelosuppression and Mucositis

F-Fluorouracil Mechanism

Folate synthesis inhibitor (TS)

Myelosuppression and Mucositis

Cytarabine Mechanism

Inhibit DNA elongations

Myelosuppression

MODULE 3

Targeted Therapy

EGFR Antibodies (6)

, Cetuximab

Erlotinib/Gefitinib

Gefitinib

Osimertinib

Trastuzumab

Lapatinib

Platelet Derived Growth Factor Receptor - PDGFR

Oluratumab

Imatinib

SERMS(2)

Tamoxifen

Raloxifene

SERDS (1)

Fulvestrant

AIs (1)

Anastrozole

Antiandrogens (1)

Enzalutamide

Ionizing Radiation (6)

Ionizing Radiation

Linear Energy Transfer (LET)

External Beam Radiation

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Number of pages: 32
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GMS6540 - ALL DRUGS EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS GRADED A++

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