GMS6540 PART 2 EXAM QUESTIONS AND ANSWERS
WITH COMPLETE SOLUTIONS VERIFIED LATEST UPDATE
gram negative bacteria
outer membrane - peptidoglycan - inner membrane
gram positive bacteria
peptidoglycan - inner membrane
B-lactam drugs inhibit
cell wall synthesis by inhibiting transpeptidase
b-lactam ring is
sterically unstable and reacts with active site of transpeptidase in a covalent fashion
adverse effects of b-lactam drugs
allergic reactions (penicillin is a hapten)
superinfection: knocks down normal flora (C. dificile)
penG and penV are identically except
penG (first developed) is IV only
PenG/V spectrum
narrow (acts on gram positive bacteria that do not produce b-lactamase)
penicillin has a short-life, but ___ can prolong its plasma levels
benzathine penG
benzathine penG treats
syphilis and rheumatic fever
, Dicloxacillin spectrum
narrow (gram positive but resistant to inactivation by B-lactamase)
Dicloxacillin is less active than ___ against gram+ organisms
PenV
Amoxicillin spectrum
extended (active against some gram+ and some gram- that are not inactivated by b-
lactamase)
Amoxicillin is less active than ___ against gram+ organisms
PenV
clavulanate + amoxicillin (Augmentin®) spectrum
broad spectrum (targets all)
clavulanate + amoxicillin is used to treat
prophylaxis for bacterial endocarditis
B-lactams cannot treat
mycobacteria (different cell wall)
mycoplasma (lacks cell wall)
cephalosporin with narrow spectrum (only gram+)
cephalexin
cephalosporin with broad spectrum
ceftriaxone
Vancomycin is different than penicillin because it directly blocks
transpeptidase (bactericidal)
vancomycin spectrum
WITH COMPLETE SOLUTIONS VERIFIED LATEST UPDATE
gram negative bacteria
outer membrane - peptidoglycan - inner membrane
gram positive bacteria
peptidoglycan - inner membrane
B-lactam drugs inhibit
cell wall synthesis by inhibiting transpeptidase
b-lactam ring is
sterically unstable and reacts with active site of transpeptidase in a covalent fashion
adverse effects of b-lactam drugs
allergic reactions (penicillin is a hapten)
superinfection: knocks down normal flora (C. dificile)
penG and penV are identically except
penG (first developed) is IV only
PenG/V spectrum
narrow (acts on gram positive bacteria that do not produce b-lactamase)
penicillin has a short-life, but ___ can prolong its plasma levels
benzathine penG
benzathine penG treats
syphilis and rheumatic fever
, Dicloxacillin spectrum
narrow (gram positive but resistant to inactivation by B-lactamase)
Dicloxacillin is less active than ___ against gram+ organisms
PenV
Amoxicillin spectrum
extended (active against some gram+ and some gram- that are not inactivated by b-
lactamase)
Amoxicillin is less active than ___ against gram+ organisms
PenV
clavulanate + amoxicillin (Augmentin®) spectrum
broad spectrum (targets all)
clavulanate + amoxicillin is used to treat
prophylaxis for bacterial endocarditis
B-lactams cannot treat
mycobacteria (different cell wall)
mycoplasma (lacks cell wall)
cephalosporin with narrow spectrum (only gram+)
cephalexin
cephalosporin with broad spectrum
ceftriaxone
Vancomycin is different than penicillin because it directly blocks
transpeptidase (bactericidal)
vancomycin spectrum
