GMS6540: PROBLEM SETS REVIEW EXAM 1 QUESTIONS AND
ANSWERS WITH COMPLETE SOLUTIONS VERIFIED LATEST
UPDATE
A patient undergoes outpatient surgery and is given a standard course of
antibiotics but ends up back in the hospital a couple days later with a severe
clostridium difficile infection. This is an example of which toxicity/complication?
superinfection
Gram positive bacteria lack what structure when compared to gram negative
bacteria
outer membrane
Which class of antibacterials is bactericidal?
Sulfonamides
Tetracyclines
Macrolides
Fluorquinolones
Clindamycins
Fluoroquinolones
A patient has an infection caused by anaerobic gram negative bacteria. Which
antibacterial would be the worst choice to treat this infection?
A tetracycline
,Ciproloxacin
Clindamycin
Metronidazole
Ciprofloxacin
Beta Lactams inhibit the proper formation of which part of the bacterial cell wall?
Peptidoglycan
In order to induce an allergic reaction, penicillin must first covalently bind to
____.
protein
Which Beta Lactam drug is active against cell wall synthesis in Beta lactamase
expressing bacteria?
Dicloxacillin
Which drug may be used as a noncompetitive inhibitor of Beta lactamase?
Clavulanate
Which drug should not be given orally for systemic infection
Penicillin
Clavulanate
Vancomycin
Dicloxacillin
Amoxicillin
Vancomycin
Sulfanilomide inhibits what enzyme?
Dihydropteroate synthase
, Trimethoprim inhibits what enzyme?
Dihydrofolate reductase
In which type of patient would sulfamethaxazole not be appropriate for treating a
bacterial infection
Cancer chemotherapy
A dose of bactrim contains trimethoprim and sulfamethoxazole in a 1:5 ratio.
Once in the blood, this is a 1:20 ratio. Which drug has the greater bioavailability?
Sulfamethoxazole
Which bacterial mechanism of resistance is shared by both sulfonamides and
trimethoprim?
Altered drug target
Sulfonamides can alter concentrations of other drugs in the body. In general,
taking sulfonamides would be expected to ____ the plasma concentration of
these other drugs. (increase or decrease)
increase
What type of immune cells begins the sequence of events that leads to organ
transplant rejection?
antigen presenting cells
An activated T cell induces T cell proliferation through the production of what
signaling molecule?
IL2
corticosteroids act as immunosuppressants most directly through the inhibition
of what mechanism?
ANSWERS WITH COMPLETE SOLUTIONS VERIFIED LATEST
UPDATE
A patient undergoes outpatient surgery and is given a standard course of
antibiotics but ends up back in the hospital a couple days later with a severe
clostridium difficile infection. This is an example of which toxicity/complication?
superinfection
Gram positive bacteria lack what structure when compared to gram negative
bacteria
outer membrane
Which class of antibacterials is bactericidal?
Sulfonamides
Tetracyclines
Macrolides
Fluorquinolones
Clindamycins
Fluoroquinolones
A patient has an infection caused by anaerobic gram negative bacteria. Which
antibacterial would be the worst choice to treat this infection?
A tetracycline
,Ciproloxacin
Clindamycin
Metronidazole
Ciprofloxacin
Beta Lactams inhibit the proper formation of which part of the bacterial cell wall?
Peptidoglycan
In order to induce an allergic reaction, penicillin must first covalently bind to
____.
protein
Which Beta Lactam drug is active against cell wall synthesis in Beta lactamase
expressing bacteria?
Dicloxacillin
Which drug may be used as a noncompetitive inhibitor of Beta lactamase?
Clavulanate
Which drug should not be given orally for systemic infection
Penicillin
Clavulanate
Vancomycin
Dicloxacillin
Amoxicillin
Vancomycin
Sulfanilomide inhibits what enzyme?
Dihydropteroate synthase
, Trimethoprim inhibits what enzyme?
Dihydrofolate reductase
In which type of patient would sulfamethaxazole not be appropriate for treating a
bacterial infection
Cancer chemotherapy
A dose of bactrim contains trimethoprim and sulfamethoxazole in a 1:5 ratio.
Once in the blood, this is a 1:20 ratio. Which drug has the greater bioavailability?
Sulfamethoxazole
Which bacterial mechanism of resistance is shared by both sulfonamides and
trimethoprim?
Altered drug target
Sulfonamides can alter concentrations of other drugs in the body. In general,
taking sulfonamides would be expected to ____ the plasma concentration of
these other drugs. (increase or decrease)
increase
What type of immune cells begins the sequence of events that leads to organ
transplant rejection?
antigen presenting cells
An activated T cell induces T cell proliferation through the production of what
signaling molecule?
IL2
corticosteroids act as immunosuppressants most directly through the inhibition
of what mechanism?
