GMS6551 FINAL_1 EXAM QUESTIONS AND ANSWERS WITH
COMPLETE SOLUTIONS
in vitro
- test tube
- cell culture
in vivo
- living animals
ex vivo
- tissue
in vitro advantages
- fast
- inexpensive
- less "red tape"
- clean systems
in vitro disadvantages
- not an animal
in vivo advantage
- results more likely to translate to humans
in vivo disadvantage
- more expensive
- may cause suffering to animals
, - regulations
- complex systems
lead compound
first compound that gives desired activity (rarely, if ever, end-result)
high-thru put testing
- expensive (done by big pharma)
- tests thousands or millions of compounds
rational drug design
- can side effects of other drugs be utilized
- alter natural ligands (ex: histamines)
molecular docking
- fast
- cheap/free computer program
- calculates chemical attractions of drugs w proteins (but doesn't take different protein
conformations and the cell membrane into account)
structure activity relationships
- optimize the lead compound
- makes better drug
- eliminates unneeded functional units to reduce off-target effects
pharmacokinetics includes
- dose of drug
- drug circulation
COMPLETE SOLUTIONS
in vitro
- test tube
- cell culture
in vivo
- living animals
ex vivo
- tissue
in vitro advantages
- fast
- inexpensive
- less "red tape"
- clean systems
in vitro disadvantages
- not an animal
in vivo advantage
- results more likely to translate to humans
in vivo disadvantage
- more expensive
- may cause suffering to animals
, - regulations
- complex systems
lead compound
first compound that gives desired activity (rarely, if ever, end-result)
high-thru put testing
- expensive (done by big pharma)
- tests thousands or millions of compounds
rational drug design
- can side effects of other drugs be utilized
- alter natural ligands (ex: histamines)
molecular docking
- fast
- cheap/free computer program
- calculates chemical attractions of drugs w proteins (but doesn't take different protein
conformations and the cell membrane into account)
structure activity relationships
- optimize the lead compound
- makes better drug
- eliminates unneeded functional units to reduce off-target effects
pharmacokinetics includes
- dose of drug
- drug circulation
