GMS6551 FINAL TEST EXAM QUESTIONS AND ANSWERS BY
EXPERTS WITH COMPLETE SOLUTIONS VERIFIED GRADED A++
What is drug discovery?
Process of finding new medications
What factors influence the choice of target diseases?
Pharma, market size, government incentives
What is a drug target?
Molecule that the drug interacts with (enzyme, receptor, RNA, DNA, protein)
What is selectivity in drug targeting?
Target determines side effects
What are the advantages of in vitro assays?
Cheaper, faster, clean system
What are the disadvantages of in vitro assays?
Not an animal, may not transfer to humans
What are the advantages of in vivo assays?
Results more likely to transfer to humans, complex systems
What are the disadvantages of in vivo assays?
More expensive, more red tape, animals may suffer
What are the methods for identifying a lead compound?
Natural products, chemical banks, rational drug design
What is molecular docking?
, Program calculates chemical attraction between drug and protein
What is SAR?
Structure-activity relationship, optimizing lead compound
What is pharmacokinetics?
Absorption, distribution, metabolism, excretion of drugs
What is HCV?
Viral disease with expensive but effective treatment
How many prescription/OTC drugs are there?
Around 20,000
What is pharmacology?
the science of how drugs act on biological systems and how the body responds
to the drug. Study of drugs and their effects on the body
What are the different areas of pharmacology?
Pharmacokinetics, pharmacodynamics, pharmacogenetics, pharmacotherapeutics,
toxicology
What is a drug?
Any substance that interacts and modulates a living system
What is assay development?
Process of developing methods to test drugs
What is ex vivo?
Testing on tissues outside of the body
What is an agonist?
Drug that activates biologic response
EXPERTS WITH COMPLETE SOLUTIONS VERIFIED GRADED A++
What is drug discovery?
Process of finding new medications
What factors influence the choice of target diseases?
Pharma, market size, government incentives
What is a drug target?
Molecule that the drug interacts with (enzyme, receptor, RNA, DNA, protein)
What is selectivity in drug targeting?
Target determines side effects
What are the advantages of in vitro assays?
Cheaper, faster, clean system
What are the disadvantages of in vitro assays?
Not an animal, may not transfer to humans
What are the advantages of in vivo assays?
Results more likely to transfer to humans, complex systems
What are the disadvantages of in vivo assays?
More expensive, more red tape, animals may suffer
What are the methods for identifying a lead compound?
Natural products, chemical banks, rational drug design
What is molecular docking?
, Program calculates chemical attraction between drug and protein
What is SAR?
Structure-activity relationship, optimizing lead compound
What is pharmacokinetics?
Absorption, distribution, metabolism, excretion of drugs
What is HCV?
Viral disease with expensive but effective treatment
How many prescription/OTC drugs are there?
Around 20,000
What is pharmacology?
the science of how drugs act on biological systems and how the body responds
to the drug. Study of drugs and their effects on the body
What are the different areas of pharmacology?
Pharmacokinetics, pharmacodynamics, pharmacogenetics, pharmacotherapeutics,
toxicology
What is a drug?
Any substance that interacts and modulates a living system
What is assay development?
Process of developing methods to test drugs
What is ex vivo?
Testing on tissues outside of the body
What is an agonist?
Drug that activates biologic response
