REVIEW EXAM GMS6551 QUESTIONS AND ANSWERS VERIFIED
LATEST UPDATE
steady state
maintain constant level of med over time
dosing schedule steady state
replace drug as it is eliminated. rate infusion = rate drug elimination;
most use intermittent dosing
quantitative pharmacokinetics
ADME => fate of drug in body
design dose regimens
understand time course
first order elimination (non-saturating)
glomerular filtration
-proportional to drug in plasma
diffusion and ion trapping
active renal sec
metabolic process
-at low substrate conc
michaelis-menten equation
rate of catalysis (enzyme) = kcat [enzyme][drug]/km+[drug]
first order when
LATEST UPDATE
steady state
maintain constant level of med over time
dosing schedule steady state
replace drug as it is eliminated. rate infusion = rate drug elimination;
most use intermittent dosing
quantitative pharmacokinetics
ADME => fate of drug in body
design dose regimens
understand time course
first order elimination (non-saturating)
glomerular filtration
-proportional to drug in plasma
diffusion and ion trapping
active renal sec
metabolic process
-at low substrate conc
michaelis-menten equation
rate of catalysis (enzyme) = kcat [enzyme][drug]/km+[drug]
first order when
