GMS6551 DRUG DISCOVERY AND NOMENCLATURE EXAM QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS

GMS6551 DRUG DISCOVERY AND NOMENCLATURE EXAM

QUESTIONS AND ANSWERS WITH COMPLETE SOLUTIONS

name examples of drug targets

-enzyme

-receptor

-other protein

-DNA

-RNA

___ determines the side effects.

target

what is it easier to target?

non-human proteins

3 types of assay development. what's used most?

1. in vitro (test tube, cell culture) - USED MOST

2. in vivo (living animals)

3. ex vivo (tissue)

in vitro testing

a. advantages

b. disadvantages

a. -fast (100s/1000s per day)

-inexpensive

, -less "red tape"

-clean systems (GOOD & BAD)

b. test tube or cell is not an animal (GOOD & BAD)

in vivo

a. advantages

b. disadvantages

a. results more likely to translate to humans

b. -more expensive

-may cause suffering to animals

-regulations

-complex systems (GOOD & BAD)

Steps to Drug Discovery and Development

1. identify a lead compound

2. design with computer (molecular docking)

3. optimize the lead compound

what's the first compound we find that has the activity we want?

lead compound

examples of natural products that lead compounds?

-plants

-algae

-bacteria

-fungi

3 ways to identify lead compound